109746-28-3Relevant academic research and scientific papers
Functionalization of 3,5,6-Trialkyl-4-hydroxy-2-pyrones in the 6-α Position
Koester, Gerhard,Hoffmann, Reinhard W.
, p. 987 - 990 (2007/10/02)
The preparation of 6-ethyl-4-hydroxy-3,5-dimethyl-2-pyrone (5) has been improved.Selective functionalization in the 6-α position of the pyrone 5 was possible by converting it into the 4-acetoxy compound 11 followed by selenium dioxide oxidation to the alcohol 13.The latter could be oxidized to the ketone 17 or be converted via the bromide 12 into other 2-pyrones having a hetero substituent in the 6-α position.
