1097635-77-2Relevant academic research and scientific papers
Alternating chiral selectivity of aldol reactions under the confined space of mesoporous silica
Yeh, Chewei,Sun, Yan-Ru,Huang, Shing-Jong,Tsai, Yeun-Min,Cheng, Soofin
supporting information, p. 17116 - 17119 (2015/12/01)
The chiral selectivities were altered and high diastereo- and enantio-selectivities of the products were obtained in water medium without adding acid co-catalysts when a primary-tertiary diamine catalyst was immobilized on mesoporous SBA-15 to form a recyclable catalyst for the direct asymmetric aldol reaction of cyclohexanone with p-nitrobenzaldehyde.
Asymmetric bifunctional primary aminocatalysis on magnetic nanoparticles
Luo, Sanzhong,Zheng, Xiaoxi,Cheng, Jin-Pei
supporting information; experimental part, p. 5719 - 5721 (2009/04/13)
MNP-supported chiral primary amine catalysts were developed and evaluated as asymmetric bifunctional enamine catalysts in direct aldol reaction, showing essentially unchanged activity and stereoselectivity after 11 recycles. The Royal Society of Chemistry
Structural optimization of thiourea-based bifunctional organocatalysts for the highly enantioselective dynamic kinetic resolution of azlactones
Berkessel, Albrecht,Mukherjee, Santanu,Mueller, Thomas N.,Cleemann, Felix,Roland, Katrin,Brandenburg, Marc,Neudoerfl, Joerg-M.,Lex, Johann
, p. 4319 - 4330 (2008/09/18)
This article describes the synthesis of a library of structurally diverse bifunctional organocatalysts bearing both a quasi-Lewis acidic (thio)urea moiety and a Bronsted basic tertiary amine group. Sequential modification of the modular catalyst structure and subsequent screening of the compounds in the alcoholytic dynamic kinetic resolution (DKR) of azlactones revealed valuable structure-activity relationships. In particular, a "hit-structure" was identified which provides e.g. N-benzoyl-tert-leucine allyl ester in an excellent enantiomeric excess of 95%. The Royal Society of Chemistry 2006.
