1097640-33-9Relevant academic research and scientific papers
Mannich reaction of 5-hydroxy-β-carboline. Application to the synthesis of novel oxazinopyrimidocarboline derivatives
Issa, Samar,Walchshofer, Nadia,Kassab, Issam,Gentili, Jacques,Geahchan, Aziz,Bouaziz, Zouhair
, p. 2761 - 2767 (2008)
5-Hydroxy-β-carboline 4 was synthesized and submitted to the Mannich reaction towards formaldehyde and some primary amines. It undergoes an original reaction of bis-aminomethylation-cyclisation giving the oxazinopyrimidocarboline derivatives 5a-d. The structure of these compounds was confirmed by their high-resolution mass, IR, 1H NMR and 13C NMR spectral data. The Japan Institute of Heterocyclic Chemistry.
