Heterocycles p. 2761 - 2767 (2008)
Update date:2022-09-26
Topics:
Issa, Samar
Walchshofer, Nadia
Kassab, Issam
Gentili, Jacques
Geahchan, Aziz
Bouaziz, Zouhair
5-Hydroxy-β-carboline 4 was synthesized and submitted to the Mannich reaction towards formaldehyde and some primary amines. It undergoes an original reaction of bis-aminomethylation-cyclisation giving the oxazinopyrimidocarboline derivatives 5a-d. The structure of these compounds was confirmed by their high-resolution mass, IR, 1H NMR and 13C NMR spectral data. The Japan Institute of Heterocyclic Chemistry.
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