1097699-89-2Relevant academic research and scientific papers
A convenient synthesis and biological activity of novel pyrido[4,3-d]pyrimidin-4(3H)-ones
Ren, Qingyun,Xia, ShiYan,Gu, Yucheng,Li, Baoju,He, Hongwu
, p. 647 - 652 (2015/05/13)
Fifteen novel 2-alkylamino-3-aryl-8-cyano-5-methyl-7-(methylthio)-pyrido[4,3-d]pyrimidin-4(3H)-ones 6a, 6b, 6c, 6d, 6e, 6f, 6g, 6h, 6i, 6j, 6k, 6l, 6m, 6n, 6o were designed and have been successfully synthesized via tandem aza-Wittig and annulation reacti
A convenient synthesis and biological activity of novel pyrido[4,3-d]pyrimidin-4(3H)-ones
Ren, Qingyun,Shi, Yanxia,Gu, Yucheng,Li, Baoju,He, Hongwu
, p. 285 - 290 (2014/04/17)
Fifteen novel 2-alkylamino-3-aryl-8-cyano-5-methyl-7-(methylthio)-pyrido[4, 3-d]pyrimidin-4(3H)-ones 6a, 6b, 6c, 6d, 6e, 6f, 6g, 6h, 6i, 6j, 6k, 6l, 6m, 6n, 6o were designed and have been successfully synthesized via tandem aza-Wittig and annulation reactions with the corresponding iminophosphorances 4, aryl isocyanate, and amines in good yields. Their structures were clearly verified by IR, 1H NMR, EI-MS spectroscopy and elemental analysis, and in the case of compound 6i, analyzed by single-crystal X-ray diffraction further. The preliminary results of an in vivo bioassay showed that some compounds display moderate antifungal activity.
