1097736-29-2

Basic information

• Product Name: methyl 1,1-(2-(7-chloroquinolin-4-ylamino)ethyl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate
• CAS NO: 1097736-29-2
• Molecular Weight: 408.887
• Mol File: 1097736-29-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 1,1-(2-(7-chloroquinolin-4-ylamino)ethyl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 1,1-(2-(7-chloroquinolin-4-ylamino)ethyl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate(1097736-29-2)
• EPA Substance Registry System: methyl 1,1-(2-(7-chloroquinolin-4-ylamino)ethyl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate(1097736-29-2)

Safety Data

• Hazardous Substances Data: 1097736-29-2(Hazardous Substances Data)

Upstream product

• 39533-32-9 methyl 2-isocyano-2-phenylacetate 

Relevant articles and documents

Antiplasmodial, β-haematin inhibition, antitrypanosomal and cytotoxic activity in vitro of novel 4-aminoquinoline 2-imidazolines

A novel series of 4-aminoquinoline-containing 2-imidazolines were synthesized via a one-pot 3-component condensation reaction of amine, aldehyde and isocyanoacetate. The products were obtained in high yield as well as purity and were evaluated directly against two strains of Plasmodium falciparum and Trypanosoma brucei. Compound 21 was the most active across all parasites with ED50 = 3.3 nM against a chloroquine (CQ)-sensitive 3D7 strain, ED50 = 33 nM against a CQ-resistant K1 strain and ED50 = 70 nM against T. brucei. Several compounds were able to inhibit formation of β-haematin in vitro, suggesting haemozoin formation in the malaria parasite as a possible target. On the other hand, evaluation against a human KB cell line revealed that the compounds were generally non-cytotoxic to the host cells.