39533-32-9

Upstream product

• 24461-61-8 phenylglycine methyl ester 
• 58298-90-1 N-formyl-D,L-phenylalanine methyl ester 
• 78247-61-7 formylamino-acetic acid methyl ester 
• 88333-03-3 Benzyl isocyanide 
• 616-38-6 carbonic acid dimethyl ester 
• 24461-61-8 (R)-Phenylglycine methyl ester 
• 15028-40-7 DL-2-phenylglycine methyl ester hydrochloride 
• 2835-06-5 phenylglycin 

Downstream Products

• 1097736-30-5 methyl 1-(2-(7-chloroquinolin-4-ylamino)ethyl)-5-methyl-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate 
• 1097736-35-0 methyl 1-(3-(7-chloroquinolin-4-ylamino)propyl)-5-methyl-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate 
• 1097736-40-7 methyl 1-(4-(7-chloroquinolin-4-ylamino)butyl)-5-methyl-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate 
• 1097736-29-2 methyl 1,1-(2-(7-chloroquinolin-4-ylamino)ethyl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate 
• 1097736-32-7 methyl 1-(2-(7-chloroquinolin-4-ylamino)ethyl)-5-isobutyl-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate 
• 1097736-33-8 methyl 1-(2-(7-chloroquinolin-4-ylamino)ethyl)-5-(2-furfuryl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate 
• 1097736-34-9 methyl 1-(3-(7-chloroquinolin-4-ylamino)propyl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate 
• 1097736-37-2 methyl 1-(3-(7-chloroquinolin-4-ylamino)propyl)-5-isobutyl-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate 
• 1097736-38-3 methyl 1-(3-(7-chloroquinolin-4-ylamino)propyl)-5-(2-furfuryl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate 
• 1097736-39-4 methyl 1-(4-(7-chloroquinolin-4-ylamino)butyl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate 

Relevant academic research and scientific papers

Novel multicomponent reaction for the combinatorial synthesis of 2-imidazolines

(Matrix presented) The three-component condensation between an amine, an aldehyde, and an α-acidic isocyanide efficiently provides substituted 2-imidazolines in a one-pot reaction under mild conditions.

Thermolysis-Induced Two- or Multicomponent Tandem Reactions Involving Isocyanides and Sulfenic-Acid-Generating Sulfoxides: Access to Diverse Sulfur-Containing Functional Scaffolds

Direct reaction of isocyanides with some sulfenic-acid-generating sulfoxides led to the effective formation of the corresponding thiocarbamic acid S-esters in good to high yields. A multicomponent reaction involving isocyanide, sulfoxide, and a suitable nucleophile has also been developed, providing ready access to a diverse range of sulfur-containing compounds, including isothioureas, carbonimidothioic acid esters, and carboximidothioic acid esters.

Catalytic enantioselective Michael addition of α-aryl-α- isocyanoacetates to vinyl selenone: Synthesis of α,α-disubstituted α-amino acids and (+)- and (-)-trigonoliimine A

Be like Mike: The title reaction in the presence of the catalyst 1 afforded Michael adducts in excellent yields and enantioselectivities. The adducts were readily converted into α,α′-disubstituted α-amino acids. The enantioselective total synthesis of bot

Antiplasmodial, β-haematin inhibition, antitrypanosomal and cytotoxic activity in vitro of novel 4-aminoquinoline 2-imidazolines

A novel series of 4-aminoquinoline-containing 2-imidazolines were synthesized via a one-pot 3-component condensation reaction of amine, aldehyde and isocyanoacetate. The products were obtained in high yield as well as purity and were evaluated directly against two strains of Plasmodium falciparum and Trypanosoma brucei. Compound 21 was the most active across all parasites with ED50 = 3.3 nM against a chloroquine (CQ)-sensitive 3D7 strain, ED50 = 33 nM against a CQ-resistant K1 strain and ED50 = 70 nM against T. brucei. Several compounds were able to inhibit formation of β-haematin in vitro, suggesting haemozoin formation in the malaria parasite as a possible target. On the other hand, evaluation against a human KB cell line revealed that the compounds were generally non-cytotoxic to the host cells.