109789-18-6Relevant articles and documents
Research and development of an efficient synthesis of hexahydrofuro[2,3-b] furan-3-ol moiety - a key component of the HIV protease inhibitor candidates
Yu, Richard H.,Polniaszek, Richard P.,Becker, Mark W.,Cook, Charles M.,Yu, Lok Him L.
, p. 972 - 980 (2007)
A highly efficient method for synthesizing racemic hexahydrofuro[2,3-b] furan-3-ol has been developed utilizing a lanthanide catalyst, such as Yh(fod)3, to promote condensation of 23-dihydrofuran and glycolaldehyde dimer. Access to either optically enriched enantiomer of bisfuran alcohol can be obtained by using this method employing chiral ligands with the lanthanide catalyst In support of Gilead Sciences' protease inhibitor project, this method has been demonstrated to be a robust and scalable process with potential application for the construction of a variety of furo[2,3-b]furan derivatives.
Towards aflatoxins: a formal synthesis of aflatoxin B2
Eastham, Stephen A.,Ingham, Steven P.,Hallett, Michael R.,Herbert, John,Modi, Andrea,Morley, Timothy,Painter, James E.,Patel, Prakash,Quayle, Peter,Ricketts, Dean C.,Raftery, James
, p. 936 - 948 (2008/09/16)
The development of a formal synthesis of aflatoxin B2 is described, which utilizes a D?tz benzannulation reaction as a key step.
PROCESS FOR PREPARATION OF HIV PROTEASE INHIBITORS
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Page/Page column 29-30, (2008/06/13)
A process for the synthesis of bisfuran intermediates useful for preparing antiviral HIV protease inhibitor compounds is hereby disclosed.
