1097920-31-4

Basic information

• Product Name: N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N'-[3-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine
• CAS NO: 1097920-31-4
• Molecular Weight: 580.754
• Mol File: 1097920-31-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N'-[3-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N'-[3-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine(1097920-31-4)
• EPA Substance Registry System: N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N'-[3-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine(1097920-31-4)

Safety Data

• Hazardous Substances Data: 1097920-31-4(Hazardous Substances Data)

Upstream product

• 109-01-3 1-methyl-piperazine 
• 170856-37-8 3-(propan-2-ylsulphonyl)aniline 
• 80213-20-3 1-nitro-3-(propane-2-sulfonyl)benzene 
• 70415-89-3 1-nitro-3-(propan-2-ylsulfanyl)benzene 
• 537-91-7 bis(3-nitrophenyl) disulfide 
• 448-19-1 4-fluoro-2-methoxy-1-nitrobenzene 
• 761440-65-7 1-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine 

Relevant articles and documents

Discovery of N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N′-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine (ASP3026), a potent and selective anaplastic lymphoma kinase (ALK) inhibitor

Anaplastic lymphoma kinase (ALK) is a validated therapeutic target for treating echinoderm microtubule- associated protein-like 4 (EML4)-ALK positive non-small cell lung cancer (NSCLC). We synthesized a series of 1,3,5-triazine derivatives and identified ASP3026 (14a) as a potent and selective ALK inhibitor. In mice xenografted with NCI-H2228 cells expressing EML4-ALK, once-daily oral administration of 14a demonstrated dose-dependent antitumor activity. Here, syntheses and structure-activity relationship (SAR) studies of 1,3,5-triazine derivatives are described.