1097933-99-7Relevant articles and documents
Synthesis, structure, and reactivity of diazoketiminato complexes of platinum(II) and palladium(II): Cytotoxic properties of a platinum complex
Pratihar, Jahar Lal,Shee, Biswaranjan,Pattanayak, Poulami,Patra, Debprasad,Bhattacharyya, Arindam,Puranik, Vedavati G.,Hung,Chattopadhyay, Surajit
, p. 4272 - 4281 (2008/03/13)
Reaction of the 2-(arylazo)anilines Ar-N=N-C6H 4NH2 [HLnNH2; Ar = C 6H5 (HL1), p-CH3C6H 4 (HL2), p-ClC6H4 (HL3)] with K2PtCl4 in dmso affords the new PtII azoimine complexes [(HLnNH)Pt(dmso)Cl] where the chloride and dmso ligands are mutually cis. In contrast, treatment of Na2PdCl 4 with HLnNH2 in dmso gives the chloro-bridged palladium dimer [{(HLnNH)PdCl}2] as the major product along with [(HLnNH)2Pd] as the minor product. Further, the reaction of HLnNHCH2Ph with K2PtCl4 in dmso also gives [(HLnNH)Pt(dmso)Cl] whereas Na 2PdCl4 affords the ortho-palladated complexes [(L nNHCH2Ph)PdCl]. This means that the N-C(CH2Ph) bond is selectively cleaved by K2PtCl4. The reaction of [(HLnNH)Pt(dmso)Cl] with acetylacetone (acacH) gives the heteroleptic complex [(HLnNH)Pt(acac)]. [(HLnNH)-Pt(dmso)Cl] and [(HLnNH)Pt(acac)] display a reversible reductive response at -1.20 and -1.46 V vs. SCE, respectively, in their cyclic voltammograms. The nature of the redox Orbitals has been determined semi-empirically employing the EHMO method. The cytotoxicity of [(HL1NH)Pt(dmso)Cl] has been examined with HeLa cells and the sub-lethal dose (8 μM) determined by dose-dependence studies. The relative degree of apoptotic and necrotic cell death using a sub-lethal dose were measured by flow cytometry. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.
