109796-28-3Relevant academic research and scientific papers
Enzymatic Ring Expansion of Penicillins to Cephalosporins: Side Chain Specificity
Baldwin, Jack E.,Adlington, Robert M.,Coates, Janice B.,Crabbe, M. James C.,Keeping, John W.,et al.
, p. 374 - 375 (1987)
Structural variants on the acylamino-side chains of penicillins as substrates for the ring expansion enzyme from Cephalosporium acremonium CO728 show that a six carbon chain terminating in a carboxy group permits efficient conversion into cephems with the expection of δ-(L-aminoadipoyl) .
THE ENZYMATIC RING EXPANSION OF PENICILLINS TO CEPHALOSPORINS: SIDE CHAIN SPECIFICITY
Baldwin, Jack E.,Adlington, Robert M.,Crabbe, M. James,Knight, Graham,Nomoto, Takashi,et al.
, p. 3009 - 3014 (2007/10/02)
Structural variants of the acylamino side chain of penicillins have been tested as substrates for Deacetoxy/Deacetyl Cephalosporin C Synthetase from C. acremonium CO 728.A six carbon chain terminating in a carboxyl group was found to permit efficient ring expansion to cephems, with the exception of δ-(L-α-aminoadipoyl).
