1097985-77-7Relevant academic research and scientific papers
Asymmetric catalytic aza-Morita-Baylis-Hillman reaction (aza-MBH): An interesting functional group-caused reversal of asymmetric induction
Shi, Min,Qi, Ming-Juan,Liu, Xu-Guang
, p. 6025 - 6027 (2008)
A highly efficient aza-Morita-Baylis-Hillman reaction (aza-MBH reaction) of N-tosyl salicylaldehyde imines with α,β-unsaturated ketones has been achieved by using β-isocupreidine (β-ICPD) as the catalyst (10 mol%) to give the corresponding adducts in good to high yields (90%-quant.) and excellent ee's (up to 99% ee), with adducts showing the opposite absolute configuration to that of those obtained in the similar aza-MBH reaction of N-tosyl aldimines with α,β-unsaturated ketones. The Royal Society of Chemistry.
