109808-91-5

Basic information

• Product Name: C₁₉H₂₃NO₄
• Synonyms: C₁₉H₂₃NO₄
• CAS NO: 109808-91-5
• Molecular Weight: 329.396
• Mol File: 109808-91-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₃NO₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₃NO₄(109808-91-5)
• EPA Substance Registry System: C₁₉H₂₃NO₄(109808-91-5)

Safety Data

• Hazardous Substances Data: 109808-91-5(Hazardous Substances Data)

Upstream product

• 3213-29-4 2,3-dimethoxyphenethylamine 
• 86-51-1 2,3-dimethyoxybenzaldehyde 
• 4468-57-9 2-(2,3-dimethoxyphenyl)acetonitrile 

Relevant articles and documents

Synthesis and structure-activity relationship of berberine analogues in LDLR up-regulation and AMPK activation

Currently there is no approved medicine for the treatment of metabolic syndrome. A series of new derivatives of berberine (BBR) or pseudoberberine (1) was synthesized and evaluated for their activity on AMP-activated protein kinase (AMPK) activation and up-regulatory low-density-lipoprotein receptor (LDLR) gene expression, respectively. In addition, the four major metabolites of BBR in vivo were also examined for their activity on AMPK in order to further understand the chemical mechanisms responsible for its glucose-lowering efficacy. Among those BBR analogues, compound 1 exhibited the potential effect on AMPK activation and LDLR up-regulation as compared with BBR. The results suggested that compound 1 might be a multiple-target agent for the treatment of metabolic syndrome, and thus was selected as a promising drug candidate for further development.