1098224-86-2Relevant academic research and scientific papers
Synthesis and cytotoxicity of analogues of the marine secondary metabolite, 2-deoxylapachol
Sunassee, Suthananda N.,Van Wyk, Albert W.W.,Osoniyi, Omolaja,Hendricks, Denver T.,Davies-Coleman, Michael T.
, p. 677 - 679 (2007)
The syntheses of four 2-substituted 1,4 naphthoquinones, related to the marine natural product 2-deoxylapachol, are reported. All four synthetic compounds were cytotoxic to WHCO1 oesophageal cancer cells.
Cytotoxicity of lapachol, β-lapachone and related synthetic 1,4-naphthoquinones against oesophageal cancer cells
Sunassee, Suthananda N.,Veale, Clinton G.L.,Shunmoogam-Gounden, Nelusha,Osoniyi, Omalaja,Hendricks, Denver T.,Caira, Mino R.,De La Mare, Jo-Anne,Edkins, Adrienne L.,Pinto, Antonio V.,Da Silva Junior, Eufranio N.,Davies-Coleman, Michael T.
, p. 98 - 110 (2013/05/09)
Naphthoquinones have been found to have a wide range of biological activities, including cytotoxicity to cancer cells. The secondary metabolites lapachol, α- and β-lapachone and a series of 25 related synthetic 1,4-naphthoquinones were screened against the oesophageal cancer cell line (WHCO1). Most of the compounds exhibited enhanced cytotoxicity (IC50 1.6-11.7 μM) compared to the current drug of choice cisplatin (IC 50 = 16.5 μM). This study also established that the two new synthetic halogenated compounds 12a and 16a (IC50 = 3.0 and 7.3 μM) and the previously reported compound 11a (IC50 = 3.9 μM), were non-toxic to NIH3T3 normal fibroblast cells. Cell death of oesophageal cancer cells by processes involving PARP cleavage caused by 11a was shown to be associated with elevated c-Jun levels, suggesting a role for this pathway in the mechanism of action of this cohort of naphthoquinone compounds.
Metal salt mediated radical reactions of 2-substituted-1, 4-naphthoquinones
Lin, Zhen-Yu,Chen, Yu-Ling,Lee, Chih-Shone,Chuang, Che-Ping
supporting information; experimental part, p. 3876 - 3882 (2010/09/10)
The silver(II)- and manganese(III)-mediated radical reactions of 2-substituted-l, 4-naphthoquinones are described. Acyl radicals generated by the oxidative decarboxylation of αketo acids with silver(I) nitrate and persulfate undergo efficient radical addi
