109826-75-7Relevant academic research and scientific papers
PREPARATION OF SPIROKETALS BY REACTION OF ANIONS FROM 2-BENZENESULPHONYLTETRAHYDROPYRANS WITH EPOXIDES:SYNTHESIS OF THE C-11 TO C-25 FRAGMENT OF THE MILBEMYCINS
Greck, Christine,Grice, Peter,Ley, Steven V.,Wonnacott, Anne
, p. 5277 - 5280 (2007/10/02)
Deprotonation of 2-benzenesulphonyltetrahydropyrans with n-butyllithium affords anions which react with substituted epoxides to give spiroketals upon acidification.Using this approach a highly convergent synthesis of the C-11 to C-25 fragment of the milbemycins was achieved.
