109826-76-8

Upstream product

• 109826-78-0 (2R,3S)-6-Benzenesulfonyl-2,3-dimethyl-tetrahydro-pyran 
• 109826-75-7 (+)-α-<6-(tert-butyldiphenylsilyloxy)-3,5-dimethyl-2-hexenyl>oxiraneethanol 
• 92512-29-3 (2S,4S)-2,4-dihydroxypentane-1,5-diyl bis(2,4,6-triisopropyl-1-benzenesulfonate) 
• 109826-77-9 (S)-2-[(E)-(2R,7R)-8-(tert-Butyl-diphenyl-silanyloxy)-5,7-dimethyl-2-(2-trimethylsilanyl-ethoxymethoxy)-oct-4-enyl]-oxirane 
• 109905-51-3 (2S,4S)-1,2:4,5-dianhydro-3-deoxypentitol 
• 127785-46-0 (2R,3S)-tetrahydro-2,3-dimethyl-6-(phenylsulphonyl)-2H-pyran (alpha anomer) 

Downstream Products

• 127785-56-2 (+)-<2R(2E,4R),4S,6S,8R,9S>-2-<6-(tert-butyldiphenylsilyloxy)-3,5-dimethyl-2-hexenyl>-8,9-dimethyl-1,7-dioxaspiro<5.5>undecan-4-ol benzoate 
• 127785-57-3 (+)-<2R(3E,5R),4S,6S,8R,9S>-2-<6-hydroxy-3,5-dimethyl-2-hexenyl>-8,9-dimethyl-1,7-dioxaspiro<5.5>undecan-4-ol benzoate 
• 115031-05-5 (+)-<2R,4E,6(2R,4S,6S,8R,9S)>-6-(4-benzoyloxy-8,9-dimethyl-1,7-dioxaspiro<5.5>undecan-2-yl)-2,4-dimethyl-4-hexenal 
• 115031-06-6 C₄₅H₆₀O₈ 
• 115031-07-7 C₄₅H₅₈O₉ 
• 115043-15-7 C₆₁H₇₈O₈Si 

Relevant academic research and scientific papers

PREPARATION OF SPIROKETALS BY REACTION OF ANIONS FROM 2-BENZENESULPHONYLTETRAHYDROPYRANS WITH EPOXIDES:SYNTHESIS OF THE C-11 TO C-25 FRAGMENT OF THE MILBEMYCINS

Deprotonation of 2-benzenesulphonyltetrahydropyrans with n-butyllithium affords anions which react with substituted epoxides to give spiroketals upon acidification.Using this approach a highly convergent synthesis of the C-11 to C-25 fragment of the milbemycins was achieved.