109838-79-1Relevant academic research and scientific papers
Preparation of 4- and 6-desphenyl analogues of (-)-clausenamide and alternative synthesis of (+)-epi-clausenamide
Xue, Jian Jun,Zhou, Yu Mei,Yu, Xiao Ming
, p. 1261 - 1264 (2012/01/06)
4- and 6-desphenyl analogues of (-)-clausenamide, 6 and 7, were prepared in optical active form from commercially available d-pyroglutamic acid and the known racemic pyrrolidinone 13, respectively. In order to confirm the absolute stereochemistry of (+)-
4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate
Wood, Jill,Bagi, Cedo M.,Akuche, Christiana,Bacchiocchi, Antonietta,Baryza, Jeremy,Blue, Marie-Luise,Brennan, Catherine,Campbell, Ann-Marie,Choi, Soongyu,Cook, James H.,Conrad, Patricia,Dixon, Brian R.,Ehrlich, Paul P.,Gane, Todd,Gunn, David,Joe, Ted,Johnson, Jeffrey S.,Jordan, Jerold,Kramss, Richard,Liu, Peiying,Levy, Joan,Lowe, Derek B.,McAlexander, Ian,Natero, Reina,Redman, Aniko M.,Scott, William J.,Town, Christopher,Wang, Ming,Wang, Yamin,Zhang, Zhonghua
, p. 4965 - 4968 (2007/10/03)
A series of 4,5-disubstituted cis-pyrrolidinones was investigated as inhibitors of 17β-HSD II for the treatment of osteoporosis. Biochemical data for several compounds are given. Compound 42 was selected as the lead candidate.
4,5-Disubstituted cis-pyrrolidinones as inhibitors of 17β- hydroxysteroid dehydrogenase II. Part 1: Synthetic approach
Cook, James H.,Barzya, Jeremy,Brennan, Catherine,Lowe, Derek,Wang, Yamin,Redman, Anikó,Scott, William J.,Wood, Jill E.
, p. 1525 - 1528 (2007/10/03)
17β-Hydroxysteroid dehydrogenase II (17β-HSD II) antagonists may provide an important way into preventing the onset of osteoporosis. The discovery of 4,5-disubstituted cis-pyrrolidinones as 17β-HSD II inhibitors led to the development of an efficient intr
Diastereoselective and Enantioselective Total Synthesis of the Hepatoprotective Agent Clausenamide
Hartwig, Wolfgang,Born, Liborius
, p. 4352 - 4358 (2007/10/02)
The diastereoselective total synthesis of the naturally ocurring hepatoprotective agent clausenamide (3-hydroxy-5-(α-hydroxybenzyl)-1-methyl-4-phenylpyrrolidin-2-one) is described, starting from ethyl cinnamate and diethyl acetamidomalonate.The enantioselective total synthesis of optically pure (+)-clausenamide is presented.The synthesis is based on a novel method for the preparation of optically pure (2S,3S)-3-phenylglutamic acid.
