109853-28-3

Upstream product

• 109853-26-1 2-hydroxy-4-phenacyl-1,2,3,4-tetrahydropyrimidine 
• 17341-93-4 2,2,2-Trichloroethyl chloroformate 
• 13735-81-4 1-styrenyloxytrimethylsilane 

Downstream Products

• 116693-18-6 2-methoxycarbonylpropan-2-yl-4-phenacyl-1,3-bis-(2,2,2-trichloroethoxycarbonyl)-1,2,3,4-tetrahydropyrimidine 
• 116693-16-4 2-(α,α-dimethylacetonyl)-4-phenacyl-1,3-bis-(2,2,2-trichloroethoxycarbonyl)-1,2,3,4-tetrahydropyrimidine 
• 116693-20-0 3-phenyl-2-(p-tolyl)-8,9-bis-(2,2,2-trichloroethoxycarbonyl)-2,8,9-triazabicyclo<3.3.1>nona-3,6-diene 
• 116693-22-2 4-(2,2,2-trichloroethoxycarbonylamino)-2-amino>but-3-enyl phenyl ketone 
• 109853-30-7 4-phenacyl-2-phenylthio-1,3-bis-(2,2,2-trichloroethoxycarbonyl)-1,2,3,4-tetrahydropyrimidine 
• 116693-10-8 4-(2,2,2-trichloroethoxycarbonylamino)-2-but-3-enyl phenyl ketone 
• 116692-94-5 2-(p-chlorophenyl)-3-phenyl-8,9-bis-(2,2,2-trichloroethoxycarbonyl)-2,8,9-triazabicyclo<3.3.1>nona-3,6-diene 
• 116693-21-1 4-(2,2,2-trichloroethoxycarbonylamino)-2-amino>but-3-enyl phenyl ketone 
• 109853-33-0 2-ethoxy-4-phenacyl-1,3-bis-(2,2,2-trichloroethoxycarbonyl)-1,2,3,4-tetrahydropyrimidine 
• 109853-32-9 2-methoxy-4-phenacyl-1,3-bis-(2,2,2-trichloroethoxycarbonyl)-1,2,3,4-tetrahydropyrimidine 

Relevant academic research and scientific papers

SYNTHESIS OF TETRAHYDROPYRIMIDINES WITH 2-OXOALKYL GROUPS USING PYRIMIDINIUM SALTS AND ENOL SILYL ETHERS : FORMATION OF DIAZABICYCLONONA-3,6-DIENE DERIVATIVES

Reactions of N-silyl- or N-acyl-pyrimidinium salts with enol trimethylsilyl ethers were carried out to afford the adducts with a 2-oxoalkyl group, that is, 2-hydroxy-4-(2-oxoalkyl)-1,2,3,4-tetrahydro-pyrimidines (9) or the 3-acyl derivatives (8), respectively.Monoacylation of compounds (9) gave monoamides (8) in high yields.Exhaustive acylation of diamines (9) with a large excess of 2,2,2-trichloroethyl chloroformate in the presence of pyridine gave bicyclic compounds, 2-oxa-8,9-diazabicyclonona-3,6-dienes (14).By addition of trifluoroacetic acid, compounds (14) were reopened to afford 3,4-dihydropyrimidinium salts (11'), which were subjected to nucleophilic attack to give 1,2,3,4-tetrahydopyrimidines (16) in high yield.