109855-80-3Relevant academic research and scientific papers
Regioexhaustive Functionalization of the Carbocyclic Core of Isoquinoline: Concise Synthesis of Oxoaporphine Core and Ellipticine
Horváth, Dániel Vajk,Domonyi, Frigyes,Palkó, Roberta,Lomoschitz, Andrea,Soós, Tibor
, p. 2181 - 2190 (2018/03/21)
A general and versatile strategy has been developed for the functionalization of the carbocyclic core of the isoquinoline. This regioexhaustive approach employs electrophilic halogenation as a toolbox methodology and delivers highly decorated intermediates that can be further elaborated toward medicinally relevant building blocks or natural products.
FORMATION OF 3,3-DISUBSTITUTED INDOLENINES FROM INTRAMOLECULAR NITRENE REACTION WITH ISOQUINOLINE AND NAPHTHALENE MOIETIES
Miller, R. Bryan,Dugar, Sundeep,Epperson, James R.
, p. 217 - 220 (2007/10/02)
Thermolysis of azides 2,7, and 14 gave nitrenes which reacted intramolecularly with isoquinoline and naphthalene moieties to produce 3,3-disubstituted indolenines 3,8, and 15, respectively, as the major products and carbazole derivatives 1,9, and 16, respectively, as the minor products.
