109877-38-5

Basic information

• Product Name: 2-aMino-3-phenylphenol
• Synonyms: 2-aMino-3-phenylphenol
• CAS NO: 109877-38-5
• Molecular Formula: C₁₂H₁₁NO
• Molecular Weight: 185.22184
• Mol File: 109877-38-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-aMino-3-phenylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-aMino-3-phenylphenol(109877-38-5)
• EPA Substance Registry System: 2-aMino-3-phenylphenol(109877-38-5)

Safety Data

• Hazardous Substances Data: 109877-38-5(Hazardous Substances Data)

Usage

Class of compound

Phenols

Common uses

Production of dyes and pigments, synthesis of pharmaceuticals and organic materials

Potential properties

Antioxidant, anti-inflammatory

Physical characteristics

White to light beige color, solid at room temperature

Safety precautions

Toxic if swallowed or inhaled, can cause skin and eye irritation

Upstream product

• 580-51-8 [1,1'-biphenyl]-3-ol 
• 21419-74-9 2-nitro-3-hydroxybiphenyl 
• 3743-70-2 N-(2-hydroxyphenyl)benzamide 
• 591-50-4 iodobenzene 

Downstream Products

• 1396795-80-4 tert-butyl (2-oxo-4-phenyl-1,3-benzoxazol-3(2H)-yl)acetate 
• 1396795-81-5 (2-oxo-4-phenyl-1,3-benzoxazol-3(2H)-yl)acetic acid 
• 1396795-82-6 C₂₂H₁₈N₂O₃ 
• 1396795-79-1 4-phenyl-1,3-benzoxazol-2(3H)-one 

Relevant articles and documents

Access to C4-arylated benzoxazoles from 2-amidophenol through C-H activation

A Pd-catalyzed aerobic approach to access C4-aryl benzoxazoles by tandem C-H ortho-arylation and acid-mediated annulation of 2-amidophenol has been presented. The directing potential of the -NHCOR group over the -OH group was exploited for selective arylation adjacent to the amide group. Deuterium labeling experiments suggest that palladation predominantly occurs adjacent to the -NHCOR group and is the key step during benzoxazole formation. One-pot hydrolysis of the resulting C4-arylated benzoxazole was also accomplished to access structurally challenging 3-aryl aminophenols for further applications.