109878-16-2

Basic information

• Product Name: 2H-Pyrrol-2-one, 1,5-dihydro-1-(4-methylphenyl)-3-[(4-methylphenyl)amino]-5-phenyl-
• Synonyms: 5-Phenyl-1-p-tolyl-3-p-tolylamino-1,5-dihydro-pyrrol-2-one;3-(p-toluidino)-5-phenyl-1-p-tolyl-1H-pyrrol-2(5H)-one;3-p-Toluidino-5-phenyl-1-p-tolyl-5H-pyrrolon-(2);5-phenyl-1-(p-tolyl)-3-(p-tolylamino)-1H-pyrrol-2(5H)-one;3-(p-tolylamino)-5-phenyl-1-p-tolyl-1H-pyrrol-2(5H)-one
• CAS NO: 109878-16-2
• Molecular Formula: C24H22N2O
• Molecular Weight: 354.451
• Mol File: 109878-16-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2H-Pyrrol-2-one, 1,5-dihydro-1-(4-methylphenyl)-3-[(4-methylphenyl)amino]-5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyrrol-2-one, 1,5-dihydro-1-(4-methylphenyl)-3-[(4-methylphenyl)amino]-5-phenyl-(109878-16-2)
• EPA Substance Registry System: 2H-Pyrrol-2-one, 1,5-dihydro-1-(4-methylphenyl)-3-[(4-methylphenyl)amino]-5-phenyl-(109878-16-2)

Safety Data

• Hazardous Substances Data: 109878-16-2(Hazardous Substances Data)

Upstream product

• 106-49-0 p-toluidine 
• 2272-45-9 benzal-p-toluidine 
• 100-52-7 benzaldehyde 
• 600-22-6 pyruvic acid methyl ester 
• 107969-78-8 methyl benzylidenepyruvate 
• 617-35-6 2-oxo-propionic acid ethyl ester 
• 109878-27-5 5-Phenyl-3--5H-furanon-(2) 
• 93316-01-9 1-(p-tolyl)-5-phenyl-tetrahydro-2,3-pyrroledione 

Downstream Products

• 93316-01-9 1-(p-tolyl)-5-phenyl-tetrahydro-2,3-pyrroledione 

Relevant articles and documents

Uncatalyzed synthesis of 3-amino-1,5-dihydro-2H-pyrrol-2-ones

Uncatalyzed one-pot pseudo-four-component reaction of ethyl pyruvate, anilines, and aldehydes in n-hexane as solvent, under reflux, affords a variety of 3-amino-1,5-dihydro-2H-pyrrol-2-ones in high yield. n-Hexane is an excellent driving force in preparat

1-Butyl-1-methylpyrrolidinium hydrogen sulfate-promoted preparation of 1,5-diaryl-3-(arylamino)-1H-pyrrol-2(5H)-one derivatives

A convenient preparative approach for synthesis of various 1,5-diaryl-3-(arylamino)-1H-pyrrol-2(5H)-ones promoted by 1-butyl-1- methylpyrrolidinium hydrogen sulfate is developed which involves cyclocondensation of aldehydes with amines and ethyl pyruvate under ambient conditions. Graphical abstract: A convenient preparative approach for synthesis of various 1,5-diaryl-3-(arylamino)-1H-pyrrol-2(5H)-ones promoted by 1-butyl-1-methylpyrrolidinium hydrogen sulfate is developed which involves cyclocondensation of aldehydes with amines and ethyl pyruvate under ambient conditions.[Figure not available: see fulltext.]

A convenient method for the preparation of 1,5-diaryl-3-(arylamino)-1H- pyrrol-2(5H)-ones

A simple and eco-friendly method for the preparation of 1,5-diaryl-3-(arylamino)-1H-pyrrol-2(5H)-ones via the cyclo-condensation reaction of aldehydes, amines and ethyl pyruvate in the presence of silica supported ferric chloride (SiO2-FeCl3) as reusable heterogeneous catalyst is described. The present methodology offers several advantages such as excellent yields, simple procedure and short reaction times. A simple and eco-friendly method for the preparation of 1,5-diaryl-3-(arylamino) -1H-pyrrol-2(5H)-ones via the cyclo-condensation reaction of aldehydes, amines and ethyl pyruvate in the presence of silica supported ferric chloride (SiO 2-FeCl3) as reusable heterogeneous catalyst is described. The present methodology offers several advantages such as excellent yields, simple procedure and short reaction times. Copyright