109879-35-8Relevant academic research and scientific papers
Immunosuppressive effects of pteridine derivatives
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, (2008/06/13)
Novel poly-substituted pteridinediones (lumazines), and mono- or polysubstituted 2-thiolumazines, 4-thiolumazines or 2,4-dithiolumazines, having disclosed substituents in positions 1, 3, 6 and 7 of the pteridine ring, and pharmaceutically acceptable salts thereof, being represented by the general formula (I). are useful as biologically active ingredients in preparing pharmaceutical compositions especially for the treatment or prevention of a CNS disorder, a cell proliferative disorder, a viral infection, an immune or auto-immune disorder or a transplant rejection. Combinations of the pteridine derivatives of the invention with an immunosuppressant or immunomodulator drug, an antineoplastic drug or an antiviral agent, providing potential synergistic effects, are also disclosed.
Immunosuppressive effects of pteridine derivatives
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Page 26, (2010/02/05)
Novel poly-substituted pteridinediones (lumazines), and mono- or polysubstituted 2-thiolumazines, 4-thiolumazines or 2,4-dithiolumazines, having disclosed substituents in positions 1, 3, 6 and 7 of the pteridine ring, and pharmaceutically acceptable salts
Reactivity of 3H-Pyrimidooxadiazin-3-one towards Carbanions: Synthesis of Pteridine-2,4-diones
Giori, P.,Poli, T.,Veronese, A.C.,Vicentini, C.B.,Manfrini, M.,Guarneri, M.
, p. 1661 - 1666 (2007/10/02)
The reaction of 3H-pyrimidooxadiazin-3-one (5) with carbanions prepared in situ from compounds containing an activated methylene group afforded 6,7-disubstituted pteridine-2,4-diones 7a-m in good yields.The reaction mechanism,involving the i
