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2,4(1H,3H)-Pteridinedione, 1,3-dimethyl-7-phenyl-, commonly known as aminopterin, is a chemical compound that serves as an antineoplastic medication. It functions by inhibiting the enzyme dihydrofolate reductase, which is essential for the synthesis of DNA and RNA.

964-45-4

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964-45-4 Usage

Uses

Used in Antineoplastic Applications:
2,4(1H,3H)-Pteridinedione, 1,3-dimethyl-7-phenylis used as an antineoplastic agent for its ability to inhibit the enzyme dihydrofolate reductase, thereby disrupting the synthesis of DNA and RNA. This mechanism makes it a potential treatment for certain types of cancer.
Used in Autoimmune Disorders Treatment:
In the medical field, 2,4(1H,3H)-Pteridinedione, 1,3-dimethyl-7-phenylis used as a treatment for autoimmune disorders, leveraging its immunosuppressive properties to manage the symptoms and progression of these conditions.
Used in Psoriasis Management:
2,4(1H,3H)-Pteridinedione, 1,3-dimethyl-7-phenylis used as a therapeutic agent in the management of psoriasis, where it helps to reduce the severity of skin symptoms associated with this chronic skin condition.
Used in Leukemia Treatment Research:
Although not widely used, 2,4(1H,3H)-Pteridinedione, 1,3-dimethyl-7-phenylhas been investigated for its potential use in the treatment of leukemia, exploring its effects on cancer cells and its possible role in cancer therapy.
Used in Abortifacient Research:
2,4(1H,3H)-Pteridinedione, 1,3-dimethyl-7-phenylhas also been studied for its potential as an abortifacient, although its use in this context is limited due to its toxic side effects and the availability of safer alternatives.
However, it is important to note that due to its toxic side effects and the development of more effective and less toxic alternative medications, 2,4(1H,3H)-Pteridinedione, 1,3-dimethyl-7-phenylis no longer widely used in clinical practice.

Check Digit Verification of cas no

The CAS Registry Mumber 964-45-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,6 and 4 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 964-45:
(5*9)+(4*6)+(3*4)+(2*4)+(1*5)=94
94 % 10 = 4
So 964-45-4 is a valid CAS Registry Number.

964-45-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,3-dimethyl-7-phenylpteridine-2,4-dione

1.2 Other means of identification

Product number -
Other names 1,3-dimethyl-7-phenyllumazine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:964-45-4 SDS

964-45-4Relevant academic research and scientific papers

Solvent-free regioselective synthesis of 6- and 7-substituted pteridines under microwave irradiation

Singh,Geetanjali

, p. 136 - 138 (2007/10/03)

Reactions of 5,6-diaminouracils with α-keto aldehydes over acidic and neutral aluminum oxide under microwave irradiation gave the corresponding 6- and 7-substituted 1,2,3,4-tetrahydropteridine-2,4-diones in 63-79% yield with high regioselectivity. Pleiade

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