109935-91-3

Upstream product

• 62740-52-7 1-(2,3-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline 
• 110244-72-9 (2,3-dimethoxy-phenyl)-acetic acid-(3,4,β-trimethoxy-phenethylamide) 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 91-16-7 1,2-dimethoxybenzene 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 90-53-9 2,3-dimethoxyphenylacetic acid 
• 59276-13-0 N-(3,4-dimethoxyphenethyl)-2,3-dimethoxyphenylacetamide 
• 4722-08-1 3,4-dimethoxy-β-methoxybenzeneethanamine 

Relevant academic research and scientific papers

1,2,3-Triazole-Mediated Synthesis of 1-Methyleneisoquinolines: A Three-Step Synthesis of Papaverine and Analogues

A metal-free three-step synthesis toward functionalized 1-methyleneisoquinolines from readily available substrates is reported. First, acetal-containing 1,2,3-triazoles were prepared via a high-yielding triazolization reaction and quantitatively converted into triazolo[5,1-a]isoquinolines. Next, the acid-promoted ring opening of these fused triazoles was studied in order to obtain coupling to a diverse scope of nucleophiles, including carbon nucleophiles such as veratrole. By means of non-nucleophilic strong acids under anhydrous conditions, a series of unprecedented isoquinolines and imidazo[5,1-a]isoquinolines was synthesized.