109936-71-2Relevant academic research and scientific papers
(S)-2-amino-3-(2,5-dimethylphenyl)-1,1-diphenyl-1-propanol: Synthesis and application in enantioselective reduction of prochiral ketones
Zhang, Ya-Wen,Shen, Zong-Xuan,Gu, De-Ben,Chen, Wei-Yi,Fei, Zheng-Hao,Dai, Qing-Fei
, p. 4415 - 4420 (1996)
The title chiral amino alcohol 6 was prepared from (s)-3-(2,5-dimethylphenyl)alanine methyl ester hydrochloride by its reaction with phenyl magnesium bromide. In the presence of 2 mol% of 6, the borane reduction of prochiral ketones gave optically active secondary alcohols in high yields with the ee's ranged from 40.5 to 100%.
