(S)-2-amino-3-(2,5-dimethylphenyl)-1,1-diphenyl-1-propanol: Synthesis and application in enantioselective reduction of prochiral ketones

Article abstract of DOI:10.1080/00397919608003844

The title chiral amino alcohol 6 was prepared from (s)-3-(2,5-dimethylphenyl)alanine methyl ester hydrochloride by its reaction with phenyl magnesium bromide. In the presence of 2 mol% of 6, the borane reduction of prochiral ketones gave optically active secondary alcohols in high yields with the ee's ranged from 40.5 to 100%.

Full text of DOI:10.1080/00397919608003844

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Synthetic Communications: An
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(S)-2-Amino-3-(2,5-
dimethylphenyl)-1,1-
diphenyl-1-propanol:
Synthesis and Application in
Enantioselective Reduction of
Prochiral Ketones
Ya-Wen Zhang a , Zong-Xuan Shen a , De-Ben Gu a
Wei-Yi Chen a , Zheng-Hao Fei a & Qing-Fei Dai a
a Department of Chemistry, Suzhou University,
Suzhou, 215006, PR China
,
Available online: 23 Aug 2006
To cite this article: Ya-Wen Zhang, Zong-Xuan Shen, De-Ben Gu, Wei-Yi Chen,
Zheng-Hao Fei & Qing-Fei Dai (1996): (S)-2-Amino-3-(2,5-dimethylphenyl)-1,1-
diphenyl-1-propanol: Synthesis and Application in Enantioselective Reduction of
Prochiral Ketones, Synthetic Communications: An International Journal for Rapid
Communication of Synthetic Organic Chemistry, 26:23, 4415-4420
To link to this article: http://dx.doi.org/10.1080/00397919608003844
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