109947-70-8

Usage

InChI:InChI=1/C12H15N7O4/c1-18-10-5-6(9(13)17-18)16-19(11(5)15-3-14-10)12-8(22)7(21)4(2-20)23-12/h3-4,7-8,12,20-22H,2H2,1H3,(H2,13,17)/t4-,7-,8-,12-/m1/s1

Upstream product

• 129572-01-6 8-amino-4-(methylsulfonyl)-6-N-methyl-2-β-D-ribofuranosyl-1,2,3,5,6,7-hexaazaacenaphthylene 
• 125284-48-2 3-cyano-4-(1-methylhydrazino)-6-methylthio-1-(β-d-ribofuranosyl)-1H-pyrazolo<3.4-d>pyrimidine 
• 69259-11-6 1-(β-D-Ribofuranosyl)-3-cyano-4,6-dimethylmercaptopyrazolo<3,4-d>pyrimidine 
• 129572-02-7 8-amino-4-hydrazino-6-N-methyl-2-β-D-ribofuranosyl-1,2,3,5,6,7-hexaazaacenaphthylene 
• 125284-49-3 8-amino-6-methyl-4-methylthio-2-(β-D-ribofuranosyl)-2,6-dihydro-1,2,3,5,6,7-hexaacenaphthylene 

Relevant academic research and scientific papers

Synthesis and cytotoxicity studies of 8-amino-6-methyl-2-β-D-ribofuranosyl-1,2,3,5,6,7- hexaazaacenaphthylene (7-aza-TCN) and the corresponding 2'-deoxy- and arabinonucleoside analogues

The tricyclic nucleoside 8-amino-6-N-methyl-2-β-D-ribofuranosyl-1,2,3,5,6,7- hexaazaacenaphthylene (5) was synthesized from 8-amino-6-N-methyl-4-(methylthio)-2-β-D-ribofuranosyl-1,2,3,5,6,7- hexaazaacenaphthylene (2). The 2'-deoxy analogue of 5, 8-amino-6-N-methyl-2-(2-deoxy-β-D-ribofuranosyl)-1,2,3,5,6,7- hexaazaacenaphthylene (11), and the arabino analogue of (5), 8-amino-6-N-methyl-2-β-D-arabinofuranosyl-1,2,3,5,6,7- hexaazaacenaphthylene (14) were synthesized from 5. Nucleosides 2, 3, 4, 5, 11, and 14 were evaluated for potential anticancer activity by measuring their ability to inhibit the growth of L1210 and H. Ep. 2 tumor cells in vitro.

AN UNUSUAL REDUCTIVE RING-OPENING OF THE 1,2,3,5,6,7-HEXAAZAACENAPHTHYLENE RING SYSTEM

Studies on an unexpected reaction involving a reductive cleavage of the pyridazine moiety of a tricyclic heterocycle are described.Structure assignments for the products obtained from the reductive cleavage were made using physicochemical methods.