109949-23-7

Basic information

• Product Name: 2-(4-methylthiazol-5-yl)ethyl 4-methylbenzenesulfonate
• Synonyms: 2-(4-methylthiazol-5-yl)ethyl 4-methylbenzenesulfonate
• CAS NO: 109949-23-7
• Molecular Weight: 297.399
• Mol File: 109949-23-7.mol

Chemical Properties

• CAS DataBase Reference: 2-(4-methylthiazol-5-yl)ethyl 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methylthiazol-5-yl)ethyl 4-methylbenzenesulfonate(109949-23-7)
• EPA Substance Registry System: 2-(4-methylthiazol-5-yl)ethyl 4-methylbenzenesulfonate(109949-23-7)

Safety Data

• Hazardous Substances Data: 109949-23-7(Hazardous Substances Data)

Upstream product

• 137-00-8 5-hydroxyethyl-4-methylthiazole 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1187465-20-8 5-chloro-2-methoxy-N-[(2Z)-5-methyl-3-[2-(4-methyl-1,3-thiazol-5-yl)ethyl]-1,3-thiazol-2(3H)-ylidene]benzamide 
• 75848-79-2 5-(2-fluoroethyl)-4-methylthiazole 

Relevant articles and documents

Artificial enzymes with thiazolium and imidazolium coenzyme mimics

Hydrophobic thiazolium and imidazolium coenzyme mimics in the presence of modified-polyethylenimine enzyme mimics catalyze the benzoin condensation 2300-3300 times faster than the coenzyme mimics alone. Polycationic enzyme mimics provide not only a hydrophobic binding domain for coenzyme and substrate, but also electrostatic stabilization of anionic species that arise along the reaction pathway of the benzoin condensation. Copyright

RADIOISOTOPE 18F SUBSTITUTED THIAMINE, AND SYNTHESIS METHOD AND USE THEREOF

The present invention discloses a radioisotope 18F substituted thiamine, synthesis method, and use thereof in small animal PET/CT imaging. The radioisotope 18F substituted thiamine has a structure of The synthesis method comprises radiochemical synthesis by using existing precursors. In the present invention, the hydroxyl in the hydroxyethyl on the thiazole cycle of thiamine is replaced by radioisotope 18F, to prepare a PET tracer. The radioisotope 18F substituted thiamine of the present invention successfully enters the brains of various strains of mice, and the uptake in the brains of thiamine-deficient mice is obviously greater than that in normal control. The present invention is useful in the preparation of a brain imaging tracer for clinical trials of Alzheimer's disease and tumors.

FLUOROETHYL THIAMINE OR SALTS THEREOF AND APPLICATION THEREOF IN PREPARATION OF ANTICOCCIDIAL DRUGS

The present invention discloses a fluoroethyl thiamine or salts thereof and application thereof in preparation of anticoccidial drugs. The structural formula of the fluoroethyl thiamine or salts thereof is shown as Formula (I). The fluoroethyl thiamine or

Fluoroethyl thiamine or salts thereof and application thereof in preparation of anticoccidial drugs

The present invention discloses a fluoroethyl thiamine or salts thereof and application thereof in preparation of anticoccidial drugs. The structural formula of the fluoroethyl thiamine or salts thereof is shown as Formula (I). The fluoroethyl thiamine or

NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS

Disclosed herein are compounds of formula (I) wherein R1, R2, R3, R25a, R26a, X, and n are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions are also described

ACTIVITE ESTEROLYTIQUE DE COMPOSES ASSOCIANT UNE FONCTION THIOL ET UNE BASE HETEROCYCLIQUE. EXEMPLES DE PROCESSUS BIFONCTIONNEL

The synthesis of 19 compounds associating a thiol function and a basic heterocycle (i.e. benzimidazole, pyridine, thiazole) is described.Their esterolytic activity towards para nitrophenyl acetate (PNPA) is compared with that of simple monofunctional thiols.The influence of the substituents and of the nature of the basic heterocycle shows that the apparition of a cooperative effect depends both on the relative pKa values (thiol and heterocyclic) and on the possibility of proton exchange via the heterocyclic moiety.Examples of bifonctional process are reported in the case of benzimidazolylmethanethiol compounds, due to a basic assistancce on the neutral form of the thiol function.