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5-(2-Hydroxyethyl)-4-methylthiazole
Cas No: 137-00-8
USD $ 1.0-1.0 / Kilogram 1 Kilogram 100 Kilogram/Month Henan Bizhi Chemical Tech Co Ltd Contact Supplier
5-(2-Hydroxyethyl)-4-methylthiazole manufacture
Cas No: 137-00-8
No Data No Data No Data Hangzhou ZeErRui Chemical Co., Ltd. Contact Supplier
4-Methyl-5-thiazoleethanol TOP1 supplier
Cas No: 137-00-8
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High quality 4-Methyl-5-Thiazoleethanol supplier in China
Cas No: 137-00-8
No Data No Data Metric Ton/Day Simagchem Corporation Contact Supplier
High quality pharmaceutical Intermediates-- 4-methyl -5-Thiazole Ethanol CAS: 137-00-8
Cas No: 137-00-8
USD $ 2.0-2.0 / Gram 100 Gram 100 Metric Ton/Month Hebei yanxi chemical co.,LTD. Contact Supplier
High quality Food grade 5-(2-Hydroxyethyl)-4-methylthiazole Cas 137-00-8 with reasonable price
Cas No: 137-00-8
USD $ 52.0-55.0 / Kilogram 5 Kilogram 60 Metric Ton/Year Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
Factory supply high quality 4-Methyl-5-thiazoleethanol,137-00-8
Cas No: 137-00-8
No Data No Data Metric Ton/Day Hubei Taiho Chemical Co.,LTD Contact Supplier
5-(2-Hydroxyethyl)-4-methylthiazole
Cas No: 137-00-8
No Data 1 Kilogram 1 Metric Ton/Month Henan Allgreen Chemical Co.,Ltd Contact Supplier
4-Methyl-5-Hydroxyethyl Thiazole
Cas No: 137-00-8
No Data No Data 5 Metric Ton/Month ORCHID CHEMICAL SUPPLIES LTD Contact Supplier
1-(4-methyl-5-thiazolyl)ethanol
Cas No: 137-00-8
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier

137-00-8 Usage

Chemical properties

It appears as colorless to pale yellow viscous oily liquid. The color will turn dark after being subject to long-term storage. It emit unpleasant thiophene compound odor with high dilution generating nut aroma. The boiling point is 103 ° C (133 Pa), or 135 ° C (933 Pa). It is easily soluble in water, soluble in ethanol, ether, benzene and chloroform.

Application

  • Used as temporarily allowable food spices;
  • For nuts, dairy products, meat products, etc., as pharmaceutical intermediates;
  • Used for the deployment of chocolate, milk and nuts

Chemical Properties

Colorless to light yellow liqui

Toxicity

GRAS (FEMA)

Usage limit FEMA

soft drinks, cold drinks, candy, baked goods, jelly, pudding, jelly sugar, seasonings, meat products, meat soup, milk and dairy products as well as cereal product: 55.0mg/kg.

Content analysis

It was determined by gas chromatography (GT-10-4) using a nonpolar column method.

Definition

ChEBI: A 1,3-thiazole that is thiazole substituted by a methyl group at position 4 and a 2-hydroxyethyl group at position 5.

Preparation

It is obtained from the reduction of 4-methyl thiazole 5-ethyl acetate reduction with lithium aluminum hydride.
InChI:InChI=1/C6H9NOS/c1-5-6(2-3-8)9-4-7-5/h4,8H,2-3H2,1H3

137-00-8 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Aldrich (190675)  4-Methyl-5-thiazoleethanol  98% 137-00-8 190675-25G 386.10CNY Detail
Alfa Aesar (A13567)  4-Methyl-5-thiazoleethanol, 98%    137-00-8 100g 644.0CNY Detail
Alfa Aesar (A13567)  4-Methyl-5-thiazoleethanol, 98%    137-00-8 25g 215.0CNY Detail

137-00-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(2-hydroxyethyl)-4-methylthiazole

1.2 Other means of identification

Product number -
Other names 4-Methyl-5-thiazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:137-00-8 SDS

137-00-8Synthetic route

acetic acid 2-(4-methyl-thiazol-5-yl)-ethyl ester
656-53-1

acetic acid 2-(4-methyl-thiazol-5-yl)-ethyl ester

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

Conditions
ConditionsYield
With water; sodium hydroxide In toluene Industrial scale;100%
With sodium hydroxide
With hydrogenchloride
1-methyl-1H-imidazole
616-47-7

1-methyl-1H-imidazole

1'-methylthiaminium diperchlorate
73333-47-8

1'-methylthiaminium diperchlorate

A

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

B

C11H17N5(2+)*2ClO4(1-)

C11H17N5(2+)*2ClO4(1-)

Conditions
ConditionsYield
In methanol for 3.5h; Heating;A n/a
B 94%
1,2-dimethyl-1H-imidazole
1739-84-0

1,2-dimethyl-1H-imidazole

1'-methylthiaminium diperchlorate
73333-47-8

1'-methylthiaminium diperchlorate

A

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

B

C12H19N5(2+)*2ClO4(1-)

C12H19N5(2+)*2ClO4(1-)

Conditions
ConditionsYield
In methanol for 3.5h; Heating;A n/a
B 94%
α-picoline
109-06-8

α-picoline

1'-methylthiaminium diperchlorate
73333-47-8

1'-methylthiaminium diperchlorate

A

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

B

C13H18N4(2+)*2ClO4(1-)

C13H18N4(2+)*2ClO4(1-)

Conditions
ConditionsYield
In methanol for 2.2h; Heating;A n/a
B 80%
picoline
108-89-4

picoline

1'-methylthiaminium diperchlorate
73333-47-8

1'-methylthiaminium diperchlorate

A

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

B

C13H18N4(2+)*2ClO4(1-)

C13H18N4(2+)*2ClO4(1-)

Conditions
ConditionsYield
In methanol for 3.8h; Heating;A n/a
B 76%
5-(2-((tert-butyldimethylsilyl)oxy)ethyl)-4-methylthiazole
273939-32-5

5-(2-((tert-butyldimethylsilyl)oxy)ethyl)-4-methylthiazole

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

Conditions
ConditionsYield
With potassium hydrogen difluoride In methanol at 60℃; for 17h;75%
pyridine-4-thiol
4556-23-4

pyridine-4-thiol

1'-methylthiaminium diperchlorate
73333-47-8

1'-methylthiaminium diperchlorate

A

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

B

4-Amino-1,2-dimethyl-5-(pyridin-4-ylsulfanylmethyl)-pyrimidin-1-ium; perchlorate

4-Amino-1,2-dimethyl-5-(pyridin-4-ylsulfanylmethyl)-pyrimidin-1-ium; perchlorate

Conditions
ConditionsYield
With sodium hydroxide In methanol for 3h; Heating;A n/a
B 71%
3,4-dichlorothiophenol
5858-17-3

3,4-dichlorothiophenol

1'-methylthiaminium diperchlorate
73333-47-8

1'-methylthiaminium diperchlorate

A

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

B

4-Amino-5-(3,4-dichloro-phenylsulfanylmethyl)-1,2-dimethyl-pyrimidin-1-ium; perchlorate

4-Amino-5-(3,4-dichloro-phenylsulfanylmethyl)-1,2-dimethyl-pyrimidin-1-ium; perchlorate

Conditions
ConditionsYield
With sodium hydroxide In methanol for 1h; Heating;A n/a
B 69%
4-cyanophenol
767-00-0

4-cyanophenol

1'-methylthiaminium diperchlorate
73333-47-8

1'-methylthiaminium diperchlorate

A

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

B

4-Amino-5-(4-cyano-phenoxymethyl)-1,2-dimethyl-pyrimidin-1-ium; perchlorate

4-Amino-5-(4-cyano-phenoxymethyl)-1,2-dimethyl-pyrimidin-1-ium; perchlorate

Conditions
ConditionsYield
With sodium hydroxide In methanol for 4h; Heating;A n/a
B 68%
3,4-Lutidin
583-58-4

3,4-Lutidin

1'-methylthiaminium diperchlorate
73333-47-8

1'-methylthiaminium diperchlorate

A

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

B

C14H20N4(2+)*2ClO4(1-)

C14H20N4(2+)*2ClO4(1-)

Conditions
ConditionsYield
In methanol for 24h; Heating;A n/a
B 64%
4-Methoxybenzenethiol
696-63-9

4-Methoxybenzenethiol

1'-methylthiaminium diperchlorate
73333-47-8

1'-methylthiaminium diperchlorate

A

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

B

4-Amino-5-(4-methoxy-phenylsulfanylmethyl)-1,2-dimethyl-pyrimidin-1-ium; perchlorate

4-Amino-5-(4-methoxy-phenylsulfanylmethyl)-1,2-dimethyl-pyrimidin-1-ium; perchlorate

Conditions
ConditionsYield
With sodium hydroxide In methanol for 1h; Heating;A n/a
B 64%
1'-methylthiaminium diperchlorate
73333-47-8

1'-methylthiaminium diperchlorate

aniline
62-53-3

aniline

A

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

B

4-Amino-1,2-dimethyl-5-phenylaminomethyl-pyrimidin-1-ium; perchlorate

4-Amino-1,2-dimethyl-5-phenylaminomethyl-pyrimidin-1-ium; perchlorate

Conditions
ConditionsYield
In methanol for 26h; Heating;A n/a
B 57%
nicotinamide
98-92-0

nicotinamide

1'-methylthiaminium diperchlorate
73333-47-8

1'-methylthiaminium diperchlorate

A

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

B

1-<(4-amino-1,2-dimethyl-5-pyrimidinio)methyl>3-carbamoylpyridinium diperchlorate

1-<(4-amino-1,2-dimethyl-5-pyrimidinio)methyl>3-carbamoylpyridinium diperchlorate

Conditions
ConditionsYield
In methanol for 72h; Heating;A n/a
B 56%
4-nitro-phenol
100-02-7

4-nitro-phenol

1'-methylthiaminium diperchlorate
73333-47-8

1'-methylthiaminium diperchlorate

A

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

B

4-Amino-1,2-dimethyl-5-(4-nitro-phenoxymethyl)-pyrimidin-1-ium; perchlorate

4-Amino-1,2-dimethyl-5-(4-nitro-phenoxymethyl)-pyrimidin-1-ium; perchlorate

Conditions
ConditionsYield
With sodium hydroxide In methanol for 3.5h; Heating;A n/a
B 54%
2,3-dichloro-2-methyl-tetrahydro-furan
13045-15-3

2,3-dichloro-2-methyl-tetrahydro-furan

thiocarboxamide
115-08-2

thiocarboxamide

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

Conditions
ConditionsYield
With pyridine; formic acid
2-ethoxy-3-chloro-2-methyl-tetrahydro-furan
663179-26-8

2-ethoxy-3-chloro-2-methyl-tetrahydro-furan

thiocarboxamide
115-08-2

thiocarboxamide

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

2-butoxy-3-chloro-2-methyl-tetrahydro-furan

2-butoxy-3-chloro-2-methyl-tetrahydro-furan

thiocarboxamide
115-08-2

thiocarboxamide

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

2-(4-methyl-2,5-dihydro-thiazol-5-yl)-ethanol
84041-80-5

2-(4-methyl-2,5-dihydro-thiazol-5-yl)-ethanol

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

Conditions
ConditionsYield
With sulfur
With potassium hexacyanoferrate(III)
5-(2-bromoethyl)-4-methyl-1,3-thiazole
671-24-9

5-(2-bromoethyl)-4-methyl-1,3-thiazole

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

Conditions
ConditionsYield
With water; potassium carbonate
VUF 8952
58981-35-4

VUF 8952

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

Conditions
ConditionsYield
With sulfuric acid; sodium nitrite
5-(2-hydroxy-ethyl)-4-methyl-3H-thiazole-2-thione
1124-01-2

5-(2-hydroxy-ethyl)-4-methyl-3H-thiazole-2-thione

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

Conditions
ConditionsYield
With hydrogenchloride; dihydrogen peroxide
With water; nickel
2-(2-bromo-4-methyl-thiazol-5-yl)-ethanol
874509-37-2

2-(2-bromo-4-methyl-thiazol-5-yl)-ethanol

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

Conditions
ConditionsYield
With sodium hydroxide; palladium on activated charcoal Hydrogenation;
With acetic acid; zinc
2-amino-5-(2-hydroxyethyl)-4-methylthiazole
1820-94-6

2-amino-5-(2-hydroxyethyl)-4-methylthiazole

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

Conditions
ConditionsYield
Diazotization.anschliessende Reduktion mit wss. H3PO2;
(i) NaNO2, aq. H2SO4, (ii) NaH2PO2; Multistep reaction;
2-amino-5-(2-hydroxyethyl)-4-methylthiazole
1820-94-6

2-amino-5-(2-hydroxyethyl)-4-methylthiazole

A

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

B

2-(2-chloro-4-methylthiazol-5-yl)ethanol
54901-54-1

2-(2-chloro-4-methylthiazol-5-yl)ethanol

Conditions
ConditionsYield
With hydrogenchloride; copper(II) sulfate Diazotization.anschliessendes Erwaermen mit CuCl;
(4-methyl-thiazol-5-yl)-acetic acid methyl ester
408334-02-1

(4-methyl-thiazol-5-yl)-acetic acid methyl ester

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

Conditions
ConditionsYield
With lithium aluminium tetrahydride; diethyl ether
(4-methyl-thiazol-5-yl)-acetic acid ethyl ester
406727-23-9

(4-methyl-thiazol-5-yl)-acetic acid ethyl ester

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

Conditions
ConditionsYield
With ethanol; sodium
With lithium aluminium tetrahydride; diethyl ether
4-methyl-5-(β-acetoxyethyl)-2-thiazolinethione
14066-76-3

4-methyl-5-(β-acetoxyethyl)-2-thiazolinethione

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

Conditions
ConditionsYield
With hydrogenchloride; dihydrogen peroxide
diethyl ether
60-29-7

diethyl ether

3-chloro-3-acetylpropanol
13045-13-1

3-chloro-3-acetylpropanol

thiocarboxamide
115-08-2

thiocarboxamide

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

3-chloro-3-acetylpropanol
13045-13-1

3-chloro-3-acetylpropanol

ethanol
64-17-5

ethanol

thiocarboxamide
115-08-2

thiocarboxamide

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

3-chloro-3-acetylpropanol
13045-13-1

3-chloro-3-acetylpropanol

thiocarboxamide
115-08-2

thiocarboxamide

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

Conditions
ConditionsYield
With α-picoline; ethyl acetate
With diethyl ether
With pyridine; ethyl acetate
With ethanol
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

methyl iodide
74-88-4

methyl iodide

3,4-dimethyl-5-(2-hydroxyethyl)thiazolium iodide
16311-69-6

3,4-dimethyl-5-(2-hydroxyethyl)thiazolium iodide

Conditions
ConditionsYield
at 60℃; for 3h; Autoclave;100%
for 2h; Reflux;96.3%
at 50℃; for 2h;96.2%
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

5-(2-bromoethyl)-4-methyl-1,3-thiazole
671-24-9

5-(2-bromoethyl)-4-methyl-1,3-thiazole

Conditions
ConditionsYield
With phosphorus tribromide In dichloromethane at 0℃; for 7h; Reflux;99%
With phosphorus tribromide
With hydrogen bromide
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

5-(2-methylsulfonyloxyethyl)-4-methylthiazole
121688-30-0

5-(2-methylsulfonyloxyethyl)-4-methylthiazole

Conditions
ConditionsYield
With triethylamine In dichloromethane at 25℃; for 4.25h; Solvent; Cooling with ice;99%
With triethylamine In dichloromethane for 1.58333h; Inert atmosphere;68%
With triethylamine In dichloromethane67%
3,4-dihydro-2H-pyran
110-87-2

3,4-dihydro-2H-pyran

5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

5-<2-<(tetrahydro-2H-pyran-2-yl)oxy>ethyl>-4-methylthiazole
166405-64-7

5-<2-<(tetrahydro-2H-pyran-2-yl)oxy>ethyl>-4-methylthiazole

Conditions
ConditionsYield
With toluene-4-sulfonic acid In dichloromethane for 8.5h; Heating;99%
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

chlormethiazole
533-45-9

chlormethiazole

Conditions
ConditionsYield
With thionyl chloride for 3h; Reflux;98%
With thionyl chloride for 2h; Heating;96%
With phosphorus pentachloride In dichloromethane for 3h; Heating;95%
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

amyl iodide
628-17-1

amyl iodide

bis(trifluoromethane)sulfonimide lithium
90076-65-6

bis(trifluoromethane)sulfonimide lithium

3-pentyl-5-(2-hydroxyethyl)-4-methylthiazolium bis(trifluoromethanesulfonyl)imide

3-pentyl-5-(2-hydroxyethyl)-4-methylthiazolium bis(trifluoromethanesulfonyl)imide

Conditions
ConditionsYield
Stage #1: 5-hydroxyethyl-4-methylthiazole; amyl iodide In acetonitrile at 60℃; for 24h; Inert atmosphere;
Stage #2: bis(trifluoromethane)sulfonimide lithium In hexane; water at 20℃; for 3h; Inert atmosphere;
98%
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

1,11-diiodoundecane
24613-66-9

1,11-diiodoundecane

1,11‐undecamethylene bis[4‐methyl‐5‐(2‐hydroxyethyl)thiazol‐3‐ium] diiodide

1,11‐undecamethylene bis[4‐methyl‐5‐(2‐hydroxyethyl)thiazol‐3‐ium] diiodide

Conditions
ConditionsYield
In acetonitrile for 72h; Inert atmosphere; Reflux;98%
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

1-(1-isocyanato-1-methylethyl)-3-(1-methylethenyl)benzene
2094-99-7

1-(1-isocyanato-1-methylethyl)-3-(1-methylethenyl)benzene

C19H24N2O2S
644985-59-1

C19H24N2O2S

Conditions
ConditionsYield
dibutyltin dilaurate In toluene at 80℃; for 4.16667h;97%
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

1,9-diiodononane
24613-65-8

1,9-diiodononane

1,9‐nonamethylene bis[4‐methyl‐5‐(2‐hydroxyethyl)thiazol‐3‐ium] diiodide

1,9‐nonamethylene bis[4‐methyl‐5‐(2‐hydroxyethyl)thiazol‐3‐ium] diiodide

Conditions
ConditionsYield
In acetonitrile for 72h; Inert atmosphere; Reflux;97%
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

4-methyl-5-(β-nitroxyethyl)thiazole

4-methyl-5-(β-nitroxyethyl)thiazole

Conditions
ConditionsYield
With nitric acid; acetic anhydride In dichloromethane at 5℃; for 2h; Temperature; Time;96.8%
With nitric acid; urea at -10 - -5℃; for 0.5h; pH=7; Nitration;82%
With sulfuric acid; nitric acid at 0 - 5℃; for 3h;53%
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

allyl bromide
106-95-6

allyl bromide

5-(2-allyloxyethyl)-4-methylthiazole
1312604-77-5

5-(2-allyloxyethyl)-4-methylthiazole

Conditions
ConditionsYield
Stage #1: 5-hydroxyethyl-4-methylthiazole With potassium tert-butylate In tetrahydrofuran at 0℃; for 1h; Inert atmosphere; Cooling with ice;
Stage #2: allyl bromide In tetrahydrofuran at 20℃; for 20h; Inert atmosphere;
96%
Stage #1: 5-hydroxyethyl-4-methylthiazole With potassium tert-butylate In tetrahydrofuran at 0℃; for 1h; Inert atmosphere;
Stage #2: allyl bromide In tetrahydrofuran at 20℃; for 20h; Inert atmosphere;
96%
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

C19H18N2O5

C19H18N2O5

2-(4-methyl-1,3-thiazol-5-yl)ethyl (2-nitro-9-oxoacridin-10-yl)-acetate

2-(4-methyl-1,3-thiazol-5-yl)ethyl (2-nitro-9-oxoacridin-10-yl)-acetate

Conditions
ConditionsYield
With sodium methylate In methanol Heating;96%
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

1,ω-diiodoheptane
51526-03-5

1,ω-diiodoheptane

1,7‐heptamethylene bis[4‐methyl‐5‐(2‐hydroxyethyl)thiazol‐3‐ium] diiodide

1,7‐heptamethylene bis[4‐methyl‐5‐(2‐hydroxyethyl)thiazol‐3‐ium] diiodide

Conditions
ConditionsYield
In acetonitrile for 72h; Inert atmosphere; Reflux;94%
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

bromoacetic acid tert-butyl ester
5292-43-3

bromoacetic acid tert-butyl ester

3-(2-tert-butoxy-2-oxoethyl)-5-(2-hydroxyethyl)-4-methylthiazol-3-ium bromide
1333480-90-2

3-(2-tert-butoxy-2-oxoethyl)-5-(2-hydroxyethyl)-4-methylthiazol-3-ium bromide

Conditions
ConditionsYield
In acetonitrile for 12h; Reflux;93.2%
In acetonitrile for 1.5h; Reflux;91.4%
In acetonitrile at 85℃;91.4%
In acetonitrile at 85℃; for 20h;
In acetonitrile for 1.5h;83.9 g
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

ethyl bromoacetate
105-36-2

ethyl bromoacetate

3-Ethoxycarbonylmethyl-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium; bromide
103871-46-1

3-Ethoxycarbonylmethyl-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium; bromide

Conditions
ConditionsYield
In ethanol for 4h; Reflux;93%
In ethanol for 2h; Heating;73%
for 3h; Reflux;50 g
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

4-ethyloctanoyl chloride
16493-81-5

4-ethyloctanoyl chloride

C16H27NO2S
1236109-84-4

C16H27NO2S

Conditions
ConditionsYield
at 70℃; for 4h;93%
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

[Re(CO)3(bpy)(MeCN)]BF4

[Re(CO)3(bpy)(MeCN)]BF4

[Re(CO)3(bpy)(4-methyl-5-thiazoleethanol)]BF4

[Re(CO)3(bpy)(4-methyl-5-thiazoleethanol)]BF4

Conditions
ConditionsYield
In chloroform for 16h; Reflux; Schlenk technique;93%
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

propargyl bromide
106-96-7

propargyl bromide

4-methyl-5-(2-(prop-2-ynyloxy)ethyl)thiazole
1417745-56-2

4-methyl-5-(2-(prop-2-ynyloxy)ethyl)thiazole

Conditions
ConditionsYield
Stage #1: 5-hydroxyethyl-4-methylthiazole With sodium hydride In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: propargyl bromide In tetrahydrofuran at 0℃;
92%
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

1-iodohexadecane
544-77-4

1-iodohexadecane

bis(trifluoromethane)sulfonimide lithium
90076-65-6

bis(trifluoromethane)sulfonimide lithium

3-hexadecyl-5-(2-hydroxyethyl)-4-methylthiazolium bis(trifluoromethanesulfonyl)imide

3-hexadecyl-5-(2-hydroxyethyl)-4-methylthiazolium bis(trifluoromethanesulfonyl)imide

Conditions
ConditionsYield
Stage #1: 5-hydroxyethyl-4-methylthiazole; 1-iodohexadecane In acetonitrile at 70℃; for 48h; Inert atmosphere;
Stage #2: bis(trifluoromethane)sulfonimide lithium In hexane; water at 20℃; for 3h; Inert atmosphere;
92%
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

N,4-dimethyl-5-[2-(hydroxy)ethyl]thiazole iodide

N,4-dimethyl-5-[2-(hydroxy)ethyl]thiazole iodide

Conditions
ConditionsYield
With methyl iodide In acetonitrile for 1.5h; Reflux;91%
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

1-Iodododecane
4292-19-7

1-Iodododecane

bis(trifluoromethane)sulfonimide lithium
90076-65-6

bis(trifluoromethane)sulfonimide lithium

3-dodecyl-5-(2-hydroxyethyl)-4-methylthiazolium bis(trifluoromethanesulfonyl)imide

3-dodecyl-5-(2-hydroxyethyl)-4-methylthiazolium bis(trifluoromethanesulfonyl)imide

Conditions
ConditionsYield
Stage #1: 5-hydroxyethyl-4-methylthiazole; 1-Iodododecane In acetonitrile at 70℃; for 49h; Inert atmosphere;
Stage #2: bis(trifluoromethane)sulfonimide lithium In hexane; water at 20℃; for 3h; Inert atmosphere;
90%
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

allyl iodid
556-56-9

allyl iodid

bis(trifluoromethane)sulfonimide lithium
90076-65-6

bis(trifluoromethane)sulfonimide lithium

3-allyl-5-(2-hydroxyethyl)-4-methylthiazolium bis(trifluoromethanesulfonyl)imide

3-allyl-5-(2-hydroxyethyl)-4-methylthiazolium bis(trifluoromethanesulfonyl)imide

Conditions
ConditionsYield
Stage #1: 5-hydroxyethyl-4-methylthiazole; allyl iodid In acetonitrile at 70℃; for 14h; Inert atmosphere;
Stage #2: bis(trifluoromethane)sulfonimide lithium In hexane; water at 20℃; for 2h; Inert atmosphere;
89%
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

suberoyl chloride
10027-07-3

suberoyl chloride

Octanedioic acid bis-[2-(4-methyl-thiazol-5-yl)-ethyl] ester
152838-60-3

Octanedioic acid bis-[2-(4-methyl-thiazol-5-yl)-ethyl] ester

Conditions
ConditionsYield
With pyridine In diethyl ether for 1.5h; Ambient temperature;88%
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

1,10-diiododecane
16355-92-3

1,10-diiododecane

1,10‐decamethylene bis[4‐methyl‐5‐(2‐hydroxyethyl)thiazol‐3‐ium] diiodide

1,10‐decamethylene bis[4‐methyl‐5‐(2‐hydroxyethyl)thiazol‐3‐ium] diiodide

Conditions
ConditionsYield
In acetonitrile for 72h; Heating;88%
In acetonitrile for 72h; Inert atmosphere; Reflux;80%
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

C20H21NO4

C20H21NO4

2-(4-methyl-1,3-thiazol-5-yl)ethyl (2-methoxy-9-oxoacridin-10-yl)-acetate

2-(4-methyl-1,3-thiazol-5-yl)ethyl (2-methoxy-9-oxoacridin-10-yl)-acetate

Conditions
ConditionsYield
With sodium methylate In methanol Heating;88%
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

C20H21NO3

C20H21NO3

2-(4-methyl-1,3-thiazol-5-yl)ethyl (4-methyl-9-oxoacridin-10-yl)-acetate

2-(4-methyl-1,3-thiazol-5-yl)ethyl (4-methyl-9-oxoacridin-10-yl)-acetate

Conditions
ConditionsYield
With sodium methylate In methanol Heating;88%
5-hydroxyethyl-4-methylthiazole
137-00-8

5-hydroxyethyl-4-methylthiazole

1-iodo-n-undecane
4282-44-4

1-iodo-n-undecane

4-methyl-5-(2-undecyloxyethyl)-1,3-thiazole

4-methyl-5-(2-undecyloxyethyl)-1,3-thiazole

Conditions
ConditionsYield
With Aliquat 336; potassium hydroxide In benzene at 80℃; for 16h; Time;88%

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