1099592-93-4Relevant academic research and scientific papers
Exploring 8-benzyl pteridine-6,7-diones as inhibitors of glutamate racemase (MurI) in Gram-positive bacteria
Breault, Gloria A.,Comita-Prevoir, Janelle,Eyermann, Charles J.,Geng, Bolin,Petrichko, Randy,Doig, Peter,Gorseth, Elise,Noonan, Brian
scheme or table, p. 6100 - 6103 (2009/07/18)
A successful scaffold-hopping approach gave a novel series of inhibitors of bacterial glutamate racemase (MurI). Early SAR studies of the 8-benzyl pteridine-6,7-diones led to compounds with micromolar enzyme potency and antibacterial activity.
