1099616-26-8

Basic information

• Product Name: N-(3,5-difluorophenyl)-2,3-dipropyl-1H-inden-1-amine
• Synonyms: N-(3,5-difluorophenyl)-2,3-dipropyl-1H-inden-1-amine
• CAS NO: 1099616-26-8
• Molecular Weight: 327.417
• Mol File: 1099616-26-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3,5-difluorophenyl)-2,3-dipropyl-1H-inden-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3,5-difluorophenyl)-2,3-dipropyl-1H-inden-1-amine(1099616-26-8)
• EPA Substance Registry System: N-(3,5-difluorophenyl)-2,3-dipropyl-1H-inden-1-amine(1099616-26-8)

Safety Data

• Hazardous Substances Data: 1099616-26-8(Hazardous Substances Data)

Upstream product

• 1942-45-6 4-Octyne 
• 26260-02-6 2-iodobenzaldehyde 
• 372-39-4 3,5-difluoroaniline 

Relevant articles and documents

Cobalt-catalyzed regioselective synthesis of indenamine from o-lodobenzaldimine and alkyne: Intriguing difference to the nickel-catalyzed reaction

A new and convenient method for the regioselective synthesis of indenamine from the corresponding o-halobenzyaldehyde, amine, and alkyne in the presence of zinc powder catalyzed by cobalt complexes, was reported. The indenamines and indene-enamine gave the corresponding imine derivatives upon treatment with TBAF in THF at 40°C. The results show that chelation-assisted oxidative addition of 2-iodo-benzaldinine to CobaltI, which is formed from the reduction of CoIII by zinc, gives a five-membered ring cobaltacycle. The nickel-catalyzed reaction and reductive elimination takes place to afford an isoquinolinium salt and then the isoquinoline product. The regiochemistry for the cobalt-catalyzed indenamine and nickel-catalyzed isoquinoline formation is opposite to each other when alkynes with an electron-withdrawing group are used.