1099672-01-1

Usage

Uses

Used in Pharmaceutical Industry:
4-Bromo-2-isopropoxybenzaldehyde is used as a reactant in the preparation of dihydrobenzopyrans, which are important scaffolds in the synthesis of various pharmaceutical compounds. The hydride transfer initiated cyclization of ortho-vinylaryl alkyl ethers allows for the efficient construction of these heterocyclic structures, which can be further modified for the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
4-Bromo-2-isopropoxybenzaldehyde serves as a valuable building block in organic synthesis, particularly for the synthesis of complex organic molecules and natural products. Its unique structural features, such as the bromine atom and isopropoxy group, can be utilized in various synthetic transformations, enabling the formation of a wide range of target molecules with diverse applications in materials science, agrochemicals, and other fields.
Used in Chemical Research:
4-Bromo-2-isopropoxybenzaldehyde is also employed as a research tool in the study of reaction mechanisms, synthetic methodologies, and the development of new catalysts and reagents. Its reactivity and structural features make it an attractive candidate for exploring novel synthetic routes and understanding the underlying principles governing various chemical transformations.

Upstream product

• 75-30-9 2-iodo-propane 
• 22532-62-3 4-bromosalicylaldehyde 
• 1099693-56-7 C₁₀H₁₃BrO₂ 

Downstream Products

• 1173178-96-5 C₁₅H₁₇BrO₅ 

Relevant academic research and scientific papers

Olefin Metathesis-Based Fluorescent Probes for the Selective Detection of Ethylene in Live Cells

Ethylene is an important plant hormone that is involved in a variety of developmental processes including agriculturally important ripening of certain fruits. Owing to its significant roles, a number of approaches have previously been developed to detect ethylene via molecular interactions. However, there are no current approaches for detection that are selective via a discrete homogeneous molecular interaction. Here we report two profluorescent chemodosimeters for the selective detection of the plant hormone ethylene. The approach consists of a BODIPY fluorophore with a pendant ruthenium recognition element based on a Hoveyda-Grubbs second generation catalysts. A marked increase in fluorescence is observed upon exposure to ethylene and selectivity is observed for ethylene over other alkenes, providing a unique approach toward ethylene detection. Imaging in live cells demonstrated that ethylene could be detected from multiple relevant sources.

SMALL-MOLECULE INHIBITORS FOR THE Β-CATENIN/B-CELL LYMPHOMA 9 PROTEIN?PROTEIN INTERACTION

Disclosed are inhibitors for the β-catenin/B-cell lymphoma 9 interaction. The inhibitors are selective for β-catenin/B-cell lymphoma 9 over β-catenin/ E-cadherin PPI interaction. Methods of using the disclosed compounds to treat cancer are also disclosed.

C-H bond functionalization via hydride transfer: synthesis of dihydrobenzopyrans from ortho-vinylaryl akyl ethers

The hydride transfer initiated cyclization ("HT-cyclization") of aryl alkyl ethers, which leads to direct coupling of sp3 C-H bonds and activated alkenes, is reported. Readily available salicylaldehyde derived ethers are converted in one step to dihydrobenzopyrans, an important class of heteroarenes frequently found in biologically active compounds. This process has not been previously reported, in contrast to known HTcyclizations of the corresponding fert-amines ("tert-amino effect" reactions).