1099675-89-4Relevant academic research and scientific papers
Stereoselective synthesis of isoxazolinobenzoxepanes via intramolecular nitrile oxide cycloaddition
Ramachandiran,Karthikeyan,Nandhakumar,Muralidharan,Perumal
scheme or table, p. 3277 - 3286 (2011/11/29)
Concise routes to the synthesis of indole-tethered nitrile oxides have been developed, and their intramolecular nitrile oxide cycloadditions were studied. Heterocyclic scaffolds involving isoxazolinobenzoxepane frameworks have been achieved via intramolecular nitrile oxide cycloaddition of 3-[1-(2- allyloxyphenyl)-2-nitroethyl]-1H-indole derivatives using (Boc)2O and DMAP. This protocol affords products with excellent trans-selectivity. Georg Thieme Verlag Stuttgart · New York.
N-heterocyclic carbene-catalyzed hydroacylation of unactivated double bonds
Hirano, Keiichi,Biju, Akkattu T.,Piel, Isabel,Glorius, Frank
supporting information; experimental part, p. 14190 - 14191 (2010/02/15)
(Chemical Equation Presented) An intramolecular N-heterocyclic carbene (NHC)-catalyzed hydroacylation of unactivated double bonds is reported. Systematic variation of the catalyst structure revealed an N- mesitylthiazolylidene annulated with a seven-membered ring to be especially reactive. This NHC enables a unique C-C bond-forming reaction to afford substituted chroman-4-ones in moderate to excellent yields, even ones containing all-carbon quaternary centers.
