1353869-47-2Relevant academic research and scientific papers
Stereoselective synthesis of isoxazolinobenzoxepanes via intramolecular nitrile oxide cycloaddition
Ramachandiran,Karthikeyan,Nandhakumar,Muralidharan,Perumal
, p. 3277 - 3286 (2011/11/29)
Concise routes to the synthesis of indole-tethered nitrile oxides have been developed, and their intramolecular nitrile oxide cycloadditions were studied. Heterocyclic scaffolds involving isoxazolinobenzoxepane frameworks have been achieved via intramolecular nitrile oxide cycloaddition of 3-[1-(2- allyloxyphenyl)-2-nitroethyl]-1H-indole derivatives using (Boc)2O and DMAP. This protocol affords products with excellent trans-selectivity. Georg Thieme Verlag Stuttgart · New York.
