109986-84-7Relevant articles and documents
Synthesis of 1-(β-D-Ribofuranosyl)indol-3-acetic Acid
Chu, Chung K.,Suh, Jungjin,Cutler, Horace G.
, p. 1777 - 1779 (2007/10/02)
By condensation of ethyl indolin-3-acetate (4) and 2,3,5-tri-O-benzoylribofuranosyl-1-acetate (5), ethyl 1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)indolin-3-acetate (6) was obtanied in good yield.The indoline nucleoside 6 was aromatized to ethyl 1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)indol-3-acetate (7) with DDQ.The treatment of the indole nucleoside with barium hydroxide and methanol gave the methyl ester 8, which was further treated in water to give the desired 1-(β-D-ribofuranosyl)indol-3-acetic acid (9).