1100049-69-1Relevant articles and documents
G-PROTEIN-CONJUGATED RECEPTOR AGONIST
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Page/Page column 31, (2010/03/02)
Disclosed is a novel aralkyl carboxylic acid compound which has an agonistic activity on GPR-120 and/or GPR-40, particularly GPR-120, and is therefore useful as an appetite regulator, an anti-obesity agent, a therapeutic agent for diabetes, a pancreatic beta differentiating cell growth enhancer, a therapeutic agent for metabolic syndrome, a therapeutic agent for a gastrointestinal disease, a therapeutic agent for a neuropathy, a therapeutic agent for a mental disorder, a therapeutic agent for a pulmonary disease, a therapeutic agent for a pituitary hormone secretion disorder or a lipid flavoring/seasoning agent. The aralkyl carboxylic acid compound is represented by the general formula (I). (I) wherein the ring Q represents a pyridyl or the like; R1 represents a C1-6 alkyl group or the like; R2 represents a hydrogen atom, a C1-4 alkyl group or a C1-4 alkoxy group; m and n independently represent an integer of 1 to 5; and X represents an oxygen atom, a sulfur atom or - NR3- [wherein R3 represents a hydrogen atom or a C1-4 alkyl group].
Identification of G protein-coupled receptor 120-selective agonists derived from PPARγ agonists
Suzuki, Takayoshi,Igari, Sou-Ichi,Hirasawa, Akira,Hata, Mie,Ishiguro, Masaji,Fujieda, Hiroki,Itoh, Yukihiro,Hirano, Tatsuya,Nakagawa, Hidehiko,Ogura, Michitaka,Makishima, Makoto,Tsujimoto, Gozoh,Miyata, Naoki
supporting information; experimental part, p. 7640 - 7644 (2009/11/30)
A weak, nonselective G protein-coupled receptor 120 (GPR 120) agonist 10 was found by screening a series of carboxylic acids derived from the peroxisome proliferator-activated receptor γ (PPARγ) agonist 3. Modification based on the homology model of GPR12
