11003-57-9Relevant academic research and scientific papers
Biomimetic chichibabin pyridine synthesis of the COPD biomarkers and elastin cross-linkers isodesmosine and desmosine
Usuki, Toyonobu,Sugimura, Takanori,Komatsu, Akira,Koseki, Yohei
, p. 1672 - 1675 (2014)
The tetrasubstituted pyridinium amino acids isodesmosine and desmosine are cross-linkers of elastin and are attractive biomarkers for the diagnosis of chronic obstructive pulmonary disease (COPD). In this study, the biomimetic total synthesis of isodesmosine and desmosine via a lanthanide-promoted Chichibabin pyridine synthesis using the corresponding aldehyde and amine hydrochloride is reported.
METHOD FOR PRODUCING DESMOSINE, ISODESMOSINE AND DERIVATIVES THEREOF
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Paragraph 0164-0167, (2015/12/19)
A process for preparing a compound represented by the following general formula (I) or a salt thereof, which comprises reacting lysine or a protective product thereof or a salt thereof with allysine or a protective product thereof in the presence of a spe
Total synthesis of COPD biomarker desmosine that crosslinks elastin
Usuki, Toyonobu,Yamada, Haruka,Hayashi, Takahiro,Yanuma, Hiroto,Koseki, Yohei,Suzuki, Noriyuki,Masuyama, Yoshiro,Lin, Yong Y.
, p. 3233 - 3235 (2012/04/10)
Desmosine, a crosslinking amino acid of elastin, is an attractive biomarker for diagnosis of chronic obstructive pulmonary disease (COPD). In this study, the first total synthesis of (+)-desmosine was achieved in 11% overall yield in 13 steps utilizing st
Total synthesis of the COPD biomarker desmosine via Sonogashira and Negishi cross-coupling reactions
Yanuma, Hiroto,Usuki, Toyonobu
supporting information, p. 5920 - 5922 (2013/01/13)
Desmosine, a crosslinking pyridinium amino acid of elastin, is an attractive biomarker for the diagnosis of chronic obstructive pulmonary disease (COPD). In this study, the total synthesis of (+)-desmosine is reported utilizing chemo- and regioselective S
