1364375-86-9

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 18163-47-8 iodoethynyltrimethylsilane 
• 108957-20-6 benzyl 2(S)-<(tert-butoxycarbonyl)amino>-3-iodopropionate 
• 18243-59-9 (2-bromoethynyl)trimethylsilane 

Downstream Products

• 11003-57-9 desmosine 
• 1364375-60-9 benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-5-{bis[2''(S)-(2''',2'''-dimethyl-3'''-(tert-butoxycarbonyl)-4'''-oxazolidin)ethyn-1''-yl]pyridin-3',5'-yl}pent-4-ynoate 
• 1364376-05-5 4-[4'-(S)-'enzyloxycarbonyl-4'-(tert-butoxycarbonyl)aminobutyl]-1-[5''(S)-benzyloxycarbonyl-5''(tert-butoxycarbonyl)aminopentyl]-3,5-bis[3'''-(S)-(tert-butoxycarbonyl)amino-3'''-carboxypropyl]pyridinium 
• 1364376-34-0 benzyl 5-{5'-[4''-(S)-benzyloxycarbonyl-4''-(tert-butoxycarbonyl)aminobut-1''-ynyl]-4'-iodopyridin-3'-yl}-2-(S)-[(tert-butoxycarbonyl)amino]pent-4-ynoate 
• 1364376-31-7 benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-5-(4',5'-diiodopyridin-3'-yl)pent-4-ynoate 
• 1364375-94-9 benzyl (S)-2-(tert-butoxycarbonyl)amino-5-[3,5-bis(2-{[(S)-2,2-dimethyl-3-tert-butoxycarbonyl-1,3-oxazolidin-4-yl]ethyl})pyridin-4-yl]pentanoate 
• 1364375-98-3 benzyl (S)-2-(tert-butoxycarbonyl)amino-5-{3,5-bis[(S)-3-(tert-butoxycarbonyl)amino-4-hydroxybutyl]pyridin-4-yl}pentanoate 
• 1364376-02-2 4,4'-{4-[(S)-4-benzyloxycarbonyl-4-(tert-butoxycarbonyl)aminobutyl]pyridin-3,5-diyl}di[(S)-2-(tert-butoxycarbonyl)aminobutanoic acid] 

Relevant academic research and scientific papers

Total synthesis of the COPD biomarker desmosine via stepwise Sonogashira cross-coupling reactions

Desmosine, a COPD biomarker and elastin crosslinker, is a tetrasubstituted pyridinium amino acid. In this paper, the total synthesis of desmosine is described utilizing stepwise and regioselective palladium-catalyzed Sonogashira cross-coupling reactions o

Total synthesis of COPD biomarker desmosine that crosslinks elastin

Desmosine, a crosslinking amino acid of elastin, is an attractive biomarker for diagnosis of chronic obstructive pulmonary disease (COPD). In this study, the first total synthesis of (+)-desmosine was achieved in 11% overall yield in 13 steps utilizing st