110064-35-2Relevant academic research and scientific papers
REACTIONS OF QUINOLINE AND 4-CHLOROQUINOLINE 1-OXIDES WITH PHENOXYACETONITRILE, CHLOROMETHYLPHENYLSULFONE, AND METHYLTHIOMETYL-p-TOLYLSULFONE
Hamana, Masatomo,Fujimura, Yasuo,Haradahira, Terushi
, p. 229 - 233 (2007/10/02)
Quinoline and 4-chloroquinoline 1-oxides react with phenoxyacetonitrile (1) and chloromethylphenylsulfone (3) in KOH-DMSO and in t-BuOK-THF to give the respective vicarious nucleophilic substitution products, 2-cyanomethyl- (2a and 2b) and 2-phenylsulfonylmethylquinoline 1-oxides (4a and 4b).The reactions with methylthiomethyl-p-tolylsulfone (5) afford not only the vicarious nucleophilic substitution products (6a and 6b) but also the products by means of hydride elimination (7a and 7b).
