59662-65-6

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
METHYLTHIOMETHYL P-TOLYL SULFONE is used as a chemical intermediate for the synthesis of various pharmaceuticals and agrochemicals, leveraging its stability and reactivity in chemical processes to produce desired end products.
Used in Polymer and Adhesive Production:
In the polymer and adhesive industries, METHYLTHIOMETHYL P-TOLYL SULFONE is utilized as a crosslinking agent, enhancing the structural integrity and performance of the final polymeric materials and adhesives through the formation of covalent bonds between polymer chains.

InChI:InChI=1/C9H12O2S2/c1-8-3-5-9(6-4-8)13(10,11)7-12-2/h3-6H,7H2,1-2H3

Upstream product

• 856343-92-5 1-methylsulfanyl-1-(toluene-4-sulfonyl)-acetone 
• 2949-92-0 methanethiosulfonic acid S-methyl ester 
• 31378-03-7 1-phenyl-2-tosylethanone 
• 2373-51-5 chloro-methylsulfanyl-methane 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 16437-69-7 (methylthio)methyl acetate 
• 657-84-1 sodium tosylate 
• 68305-26-0 S-methyl p-chlorobenzenethiosulfonate 
• 7569-26-8 chloromethyl p-tolylsulfone 
• 5188-07-8 sodium thiomethoxide 
• 22693-22-7 Methyl-propionyloxymethyl-sulfid 
• 67-68-5 dimethyl sulfoxide 
• 119555-54-3 3-Benzyloxy-1-methylsulfanyl-1-(toluene-4-sulfonyl)-propan-2-one 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 87228-75-9 2-methylthio-1-(2-thienyl)-2-(p-tolylsulfonyl)ethene 
• 98223-60-0 2-[5-Methylsulfanyl-5-(toluene-4-sulfonyl)-pentyloxy]-tetrahydro-pyran 
• 122277-45-6 1-Methyl-4-(1-methylsulfanyl-pent-4-ene-1-sulfonyl)-benzene 
• 110036-01-6 2-p-tolylsulfonylmethylquinoline 1-oxide 
• 110064-35-2 2-(methylthio-p-tolylsulfonyl)methylquinoline 1-oxide 
• 94816-47-4 1-(methylthio)-1-propyl p-tolyl sulfone 
• 162777-19-7 <(4-methylphenyl)sulfonyl>(trimethylsilyl)methyl methyl sulfide 
• 162777-24-4 Z-1,2-bis(4-methylphenylsulfonyl)-1,2-bis(methylthio)-ethylene 
• 87228-71-5 1-Methyl-4-(1-methylsulfanyl-cyclohexanesulfonyl)-benzene 
• 15733-07-0 1-bromo-4-(methylsulfanylmethyl)benzene 
• 19614-11-0 1-bromo-2-[(methylthio)methyl]benzene 
• 99764-03-1 4-Methylsulfanyl-3-phenyl-4-(toluene-4-sulfonyl)-butyric acid ethyl ester 
• 110036-02-7 4-Chloro-2-(toluene-4-sulfonylmethyl)-quinoline 1-oxide 
• 110036-03-8 4-Chloro-2-[methylsulfanyl-(toluene-4-sulfonyl)-methyl]-quinoline 1-oxide 

Relevant academic research and scientific papers

Donor substituted sulfonyl carbenes, 2: Organothio sulfonyl carbenes

Organothio sulfonyl carbenes 3 have been generated via ylid thermolysis or via α-elimination starting from α-chloro α-organothio sulfones and their derivatives. They have been captured by suitable nucleophilic trapping reagents (diazomethane, enol ethers, and other). Their nucleophilic carbenoid precursors could be trapped by an electrophilic olefin (ketene dithioacetal S,S-dioxides as Michael acceptors). Stable carbene Z-dimers could be obtained under various conditions. Bromine catalyzed isomerization to E-isomers proved to be reversible.

A NOVEL PREPARATION OF 3-METHYLTHIO-2-OXOPROPANAL ACETALS USING METHYLTHIOMETHYL p-TOLYL SULFONE

Treatment of an alkoxyacetyl derivative (3) of methylthiomethyl p-tolyl sulfone (1), easily obtainable from an alkoxyacetic ester and 1, with such a base as triethylamine or DABCO affords 3-methylthio-2-oxopropanal acetal (4).

UTILIZATION OF METHYLTHIOMETHYL p-TOLYL SULFONE IN ORGANIC SYNTHESIS

Methylthiomethyl p-tolyl sulfone was found to be one of the useful reagents for preparation of various organic compounds such as S-methyl α-ketocarbothioates, carboxylic esters, five- and six-membered cycloalkanones, and α-methoxy-α-arylacetic esters.

Convenient Preparation of Methylthiomethyl p-Tolyl Sulfone Starting from Dimethyl Sulfoxide

An efficient method for preparing methylthiomethyl p-tolyl sulfone was accomplished by the Pummerer reaction of dimethyl sulfoxide with acetic anhydride followed by treatment of the resulting acetoxymethyl methyl sulfide with sodium p-toluenesulfinate in the presence of sodium acetate in acetic acid.

A NOVEL ROUTE FROM A CARBOXYLIC ACID TO A CARBALDEHYDE USING METHYLTHIOMETHYL p-TOLYL SULFONE

A new conversion of a carboxylic ester to a carbaldehyde involing formation and dissociation of a C-C bond at the acyl carbon was accomplished by the use of methylthiomethyl p-tolyl sulfone (1).