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1100748-81-9

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1100748-81-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1100748-81-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,0,0,7,4 and 8 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1100748-81:
(9*1)+(8*1)+(7*0)+(6*0)+(5*7)+(4*4)+(3*8)+(2*8)+(1*1)=109
109 % 10 = 9
So 1100748-81-9 is a valid CAS Registry Number.

1100748-81-9Downstream Products

1100748-81-9Relevant articles and documents

Synthesis of four novel natural product inspired scaffolds for drug discovery

Jenkins, Ian D.,Lacrampe, Fabienne,Ripper, Justin,Alcaraz, Lilian,Van Le, Phuc,Nikolakopoulos, George,De Leone, Priscila Almeida,White, Rodney H.,Quinn, Ronald J.

experimental part, p. 1304 - 1313 (2009/07/04)

Inspired by the novel spiro structures of a number of bioactive natural products such as the histrionicotoxins, a series of novel spiro scaffolds have been designed and robust syntheses developed. The scaffolds are ready-to-use building blocks and can be easily prepared on a 5-20 g scale. They contain two amino groups (one Boc-protected) and have been designed for ease of conversion to a lead generation library, using either amide formation or reductive amination procedures. The synthesis of the 1,9-diazaspiro[5.5]undecane and 3,7-diazaspiro[5.6]dodecane ring systems was achieved using RCM as the key step. A simple workup procedure is reported for the removal of highly colored ruthenium residues. The synthesis of the 1,8-diazaspiro[4.5]decane scaffold has been achieved using a bromine-mediated 5-endo cyclization of the corresponding 4-aminobutene intermediate under acidic conditions. This is the first example of this type of cyclization to be reported. A novel mechanism involving a bromine transfer reaction from an initially formed bromonium ion to a neighboring nitrogen atom is suggested as the reason for the failure of this type of reaction under "normal" bromination conditions. An unusual rearrangement of a 1-acyl-1,9-diazaspiro[5.5]undecane to the corresponding 9-acyl-1,9-diazaspiro[5.5]undecane is reported.

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