1100793-97-2Relevant articles and documents
Metal–organic frameworks of Cu2(TPTC)-catalyzed cascade C–S coupling/Csp2–H hydroxylation reaction
Tian, An-Qi,Liu, Shan,Ren, Zhi-Lin,Wang, Long,Li, Dong-Sheng
, p. 1339 - 1345 (2020)
Abstract: This paper reports a novel disulfide-directed Csp2–H hydroxylation cascade reaction strategy catalyzed by Cu2(TPTC), a metal–organic framework material with binuclear Cu(II) paddlewheel nodes. In the strategy, Cu2(TPTC) MOF can effectively catalyze the coupling reaction of disulfide and arylboronic acid, and realize the disulfide-directed Csp2–H hydroxylation reaction. This reaction proceeded well under Cu2(TPTC) MOF catalyst with good yields, which provides an efficient method to the synthesis of functional organic molecules, such as 2-(phenylthio)phenols derivatives. Graphic abstract: [Figure not available: see fulltext.].
Efficient method for selectively synthesizing 2-hydroxybenzene sulfur ether compound
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Paragraph 0019; 0020, (2016/10/08)
The invention provides an efficient method for selectively synthesizing a 2-hydroxybenzene sulfur ether compound. The method includes the steps of making a thiophenol compound shown in the formula (I) and an aryl halide compound shown in the formula (II) sufficiently react in a reaction medium with dimethyl sulfoxide as solvent under the effects of a catalyst, ligand and alkali carbonate to prepare a reagent, and conducting postprocessing on the reagent to prepare the 2-hydroxybenzene sulfur ether compound, wherein cuprous iodide serves as the catalyst, enaminone serves as the ligand, and cesium carbonate serves as the alkali carbonate. R1 in the formula (I) or the formula (II) is selected from one of alkyl and halogen. R2 in the formula (II) or the formula (III) is selected from one of methoxyl, halogen and trifluoromethyl. Raw materials can be easily obtained, the synthesis condition is gentle, the chemical selectivity is high and controllable, cost is saved, the requirements for devices are low, solvent and water can dissolve each other, postprocessing is convenient, the catalytic system is wide in adaptability, and the method is suitable for large-scale industrialized production.
Diaryl sulfide-based inhibitors of trypanothione reductase: Inhibition potency, revised binding mode and antiprotozoal activities
Stump, Bernhard,Eberle, Christian,Kaiser, Marcel,Brun, Reto,Krauth-Siegel, R. Luise,Diederich, Francois
supporting information; experimental part, p. 3935 - 3947 (2009/06/28)
Trypanothione reductase (TR) is an essential enzyme of trypanosomatids and therefore a promising target for the development of new drugs against African sleeping sickness and Chagas′ disease. Diaryl sulfides with a central anilino moiety, decorated with a
