4235-20-5

Usage

Uses

Used in Agricultural Industry:
2-Amino-4-chlorodiphenylsulfide is used as a fungicide and bactericide for protecting crops such as rice, potatoes, and vegetables from diseases caused by fungi and bacteria. It functions by inhibiting the growth and reproduction of these pathogens, thereby preventing the spread of infections. Its relatively low toxicity and low potential for bioaccumulation make it an attractive option for agricultural use, although care must be taken in handling and application to avoid ingestion, inhalation, or skin and eye irritation.

InChI:InChI=1/C12H10ClNS/c13-9-6-7-12(11(14)8-9)15-10-4-2-1-3-5-10/h1-8H,14H2

Upstream product

• 4548-56-5 4-chloro-2-nitrophenyl phenyl sulfide 
• 108-98-5 thiophenol 
• 345-18-6 2-fluoro-5-chloronitrobenzene 
• 591-50-4 iodobenzene 
• 1004-00-8 4-chloro-2-aminobenzenethiol 

Downstream Products

• 1103976-09-5 C₁₆H₁₀ClNO₂S 
• 1103976-20-0 C₁₇H₁₂ClNO₂S 
• 1451261-59-8 N-[5-chloro-2-(phenylsulfanyl)phenyl]-1-benzofuran-2-sulfonamide 
• 1451261-60-1 N-[5-chloro-2-(phenylsulfonyl)phenyl]-1-benzofuran-2-sulfonamide 
• 61414-38-8 3-(N-(2-phenylthio-5-chloro)phenyl)propyldimethylamine 
• 101935-77-7 benzoic acid-(5-chloro-2-phenylsulfanyl-anilide) 
• 195073-72-4 2-Bromo-N-(5-chloro-2-phenylsulfanyl-phenyl)-acetamide 
• 195073-71-3 1-[4-(2-Amino-4-chloro-phenylsulfanyl)-phenyl]-ethanone 
• 188058-90-4 N-(3-bromopropionyl)-5-chloro-2-phenylthiophenylamide 
• 37930-75-9 5-Chlor-2-phenylthio-trifluormethansulfonanilid 
• 101096-34-8 N-(3-chloropropyl)-5-chloro-2-phenylthiophenylamine 
• 180145-03-3 (5-Chloro-2-phenylsulfanyl-phenyl)-(3-chloro-propyl)-amine 
• 1100794-07-7 (4-chloro-2-iodophenyl)(phenyl)sulfane 
• 1100793-97-2 5-chloro-2-(phenylthio)phenol 

Relevant academic research and scientific papers

Nickel-Catalyzed C?H Chalcogenation of Anilines

The C?H thiolation of aniline derivatives was accomplished with a versatile nickel(II) catalyst under ligand-free conditions. The robust nature of the nickel catalysis system was reflected by the C?H thiolation with a good functional group tolerance and an ample scope, employing anilines possessing removable directing groups. The widely applicable nickel catalyst also allowed for aniline C?H selenylations, while mechanistic studies provided strong support that the rate-determining step is the C?H activation.

Environmentally Friendly and Recyclable CuCl 2-Mediated C-S Bond Coupling Strategy Using DMEDA as Ligand, Base, and Solvent

Simple reaction conditions and recyclable reagents are crucial for environmentally friendly industrial applications. An environment-friendly, recyclable and economic strategy was developed to synthesize diaryl chalcogenides by the CuCl2-catalyzed C S bondformation reaction via iodobenzenes and benzenethiols/1,2-diphenyldisulfanes using N,N'-dimethylethane-1,2-diamine (DMEDA) as ligand, base, and solvent. For these reactions, especially the reactions of diiodobenzenes and aminobenzenethiols/disulfanediyldianilines, a range of substrates are compatible and give the corresponding products in good to excellent yields. Both of the reagents in the catalytic system (CuCl2/DMEDA) are inexpensive, conveniently separable, and recyclable for more than five cycles.

BENZOFURAN-2-SULFONAMIDES DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS

The present invention relates to novel benzofuran-2-sulfonamide derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

Diaryl sulfide-based inhibitors of trypanothione reductase: Inhibition potency, revised binding mode and antiprotozoal activities

Trypanothione reductase (TR) is an essential enzyme of trypanosomatids and therefore a promising target for the development of new drugs against African sleeping sickness and Chagas′ disease. Diaryl sulfides with a central anilino moiety, decorated with a

Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfide

Quaternization of the nitrogen atom of 2-amino-4-chlorophenyl phenyl sulfide analogues of chlorpromazine improved inhibition ～40-fold (3′,4′-dichlorobenzyl-[5-chloro-2-phenylsulfanylphenylamino)-propyl] -dimethylammonium chloride inhibited trypanothione r

NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS

The present invention provides compounds according to general Formula (I), a prodrug thereof, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of a prodrug thereof. More particularly, the present invention provides high affinity non-steroidal compounds which are agonists, partial agonists or antagonists of the progesterone receptor.

New spermine and spermidine derivatives as potent inhibitors of trypanosoma cruzi trypanothione reductase

Several spermine and spermidine derivatives containing 2-amino diphenylsulfide substituents were prepared and tested for their inhibiting effects on Trypanosoma cruzi trypanothione reductase. IC50 values were assessed between 0.3 and 3 μM. Compound 32 (K(i) = 0.4 μM) is the most potent TR inhibitor described so far.

Substituted dibenzoxazepine and dibenzthiazepine carbamate compounds, pharmaceutical compositions and methods of use

The present invention provides substituted dibenzoxazepine and dibenzthiazepine compounds of Formula I: STR1 which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a com

Substituted dibenzoxazepine and dibenzthiazepine urea compounds, pharmaceutical compositions and methods of use

The present invention provides substituted dibenzoxazepine and dibenzthiazepine compounds of Formula I: STR1 which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a com

2-,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use

The present invention provides substituted dibenzoxazepine and dibenzthiazepine compounds of Formula I: STR1 which are useful as analgesic agents for the treatment of pain, and for prostaglandin-E2 mediated diseases, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal, and a method for treating prostaglandin-E2 mediated diseases in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.