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Relevant academic research and scientific papers

Design strategy of multifunctional and high efficient hydrogen sulfide NIR fluorescent probe and its application in vivo

With the improvement of organic synthesis technology and the development of fluorescent probe, more and more fluorescent probes with excellent performance and versatility are required, so as to better realize their application value. High sensitivity, high selectivity, targetable and fast response NIR fluorescence probes are still needed for hydrogen sulfide precise detection. In this study, phenol containing 2, 4-dinitro group was selected as a strong electrophilic group to promote the nucleophilic substitution reaction. After the nucleophilic addition reaction between probe and hydrogen sulfide with delicate structure, strong nucleophile, 2, 4-dinitrophenol departure quickly and the NIR fluorophore was released, which showed fluorescence emission at 741 nm, and the probe detection limit for hydrogen sulfide was calculated as 96 nM. Interestingly, because of the positive charge in the hemiocyanine, the probe can locate efficiently in the mitochondria. This fluorescent probe with excellent performance was used to detect the endogenous levels of hydrogen sulfide in vivo. This work provides guidance for the design of multifunctional and high-performance fluorescent probes.

Cys fluorescent molecular probe for detecting DNA targeting under reduction stress as well as preparation method and application of Cys fluorescent molecular probe

The invention relates to a Cys fluorescent molecular probe for detecting DNA targeting under reduction stress as well as a preparation method and application of the Cys fluorescent molecular probe. The structural formula of the fluorescent molecular probe is as shown in the formula (1). The prominent light control characteristic of the fluorescent molecular probe is beneficial to real-time monitoring of diseases caused by errors in the DNA replication process due to abnormal expression of Cys under DNA peripheral reduction stress, and the fluorescent molecular probe is expected to be applied to prevention, treatment and the like of gene diseases caused by abnormal expression of Cys.

Near-infrared fluorescent probe for detecting Cys in brain of depression mouse as well as synthesis method and application thereof

The invention relates to a synthesis method of a near-infrared fluorescent probe for detecting Cys in brain of a depression mouse, which comprises the following steps: uniformly mixing Changsha red and phenyl chlorothioformate in a solvent, and reacting to obtain the product. The near-infrared fluorescent probe disclosed by the invention is a near-infrared fluorescent probe which is subjected to nucleophilic substitution by phenyl thioformate (a specific recognition group of Cys) and Chansa red (a fluorescent group). The method has the advantages of simple preparation, sensitive detection, good selectivity and the like. It is worth noting that by means of the method, imaging analysis of changes of Cys in the brain of the depression mouse on the living body level is successfully achieved.

Near-infrared fluorescent molecule for controlled release of singlet oxygen and preparation method thereof

The invention discloses a near-infrared fluorescent molecule for controlled release of singlet oxygen and a preparation method thereof. specifically, cyanine is used as a main structure to synthesizea compound B2, and then the compound B2 reacts with malononitrile to form a C=N double bonds to obtain a target product C2. The target compound C2 can release singlet oxygen under the irradiation of near-infrared light. Through laser irradiation with the wavelength of 635 nm, the absorbancy value reduction rate of C2 molecules at the maximum absorption wavelength is higher than that of rose bengalmolecules; the absorbancy value reduction rate of C2 molecules at 410 nm is faster than that of rose bengal molecules, i.e., the singlet oxygen generation rate is faster than that of rose bengal molecules, wherein the singlet oxygen yield of C2 molecules is 0.56.

Tumor-targeted optical contrast agents

Cyanine dye bioconjugates useful for diagnostic imaging and therapy are disclosed. The conjugates include several cyanine dyes with a variety of bis- and tetrakis (carboxylic acid) homologs. The compounds may be conjugated to bioactive peptides, carbohydr