Dyes and Pigments (2021)
Update date:2022-07-30
Topics:
Jin, Ming
Yang, Yutao
Yin, Caixia
Zhou, Keyan
Zhou, Tingting
With the improvement of organic synthesis technology and the development of fluorescent probe, more and more fluorescent probes with excellent performance and versatility are required, so as to better realize their application value. High sensitivity, high selectivity, targetable and fast response NIR fluorescence probes are still needed for hydrogen sulfide precise detection. In this study, phenol containing 2, 4-dinitro group was selected as a strong electrophilic group to promote the nucleophilic substitution reaction. After the nucleophilic addition reaction between probe and hydrogen sulfide with delicate structure, strong nucleophile, 2, 4-dinitrophenol departure quickly and the NIR fluorophore was released, which showed fluorescence emission at 741 nm, and the probe detection limit for hydrogen sulfide was calculated as 96 nM. Interestingly, because of the positive charge in the hemiocyanine, the probe can locate efficiently in the mitochondria. This fluorescent probe with excellent performance was used to detect the endogenous levels of hydrogen sulfide in vivo. This work provides guidance for the design of multifunctional and high-performance fluorescent probes.
View MoreChangzhou LanXu Chemical Co.,ltd.(expird)
Contact:86-0519-86330911,13656129734,15261186386
Address:Room 524, Depart.Chemical, Changzhou Science and Eductaion town, Jiangsu, China;Factory: Haian Fine Chemical Industry Park,Nantong,Jiangsu,China
SHANDONG QINGYUNCHANGXIN CHEMICAL SCIENCE-TECH CO.,LTD
Contact:86-21-60560171
Address:1689Donghuan Rade,Qingyun County, Dezhou City, Shandong,China
Shenyang NovPharm Technology Co., Ltd.
Contact:.+86-24-24165786
Address:Room 306, Hongjin Mansion, No. 36-1, Wanliutang Rd., Shenhe District, Shenyang, Liaoning, P.R.C.
Nanjing Fubang Chemical Co.,Ltd
Contact:+86-25-83179199
Address:5F,Tianzheng international plaza,No399 Zhongyang Road ,Nanjing China
website:http://www.acrospharmatech.com
Contact:+1-3234804688
Address:Flat/RM 1502,Easey Commercial building 253-261 Hennessy Road,Wanchai,HongKong
Doi:10.1021/om000606w
(2000)Doi:10.1021/jo00231a040
(1987)Doi:10.1021/jm500522y
(2014)Doi:10.1016/S0040-4039(00)99086-5
(1989)Doi:10.1002/ardp.19883210115
(1988)Doi:10.1002/bkcs.10067
(2015)