Dyes and Pigments (2021)
Update date:2022-07-30
Topics:
Jin, Ming
Yang, Yutao
Yin, Caixia
Zhou, Keyan
Zhou, Tingting
With the improvement of organic synthesis technology and the development of fluorescent probe, more and more fluorescent probes with excellent performance and versatility are required, so as to better realize their application value. High sensitivity, high selectivity, targetable and fast response NIR fluorescence probes are still needed for hydrogen sulfide precise detection. In this study, phenol containing 2, 4-dinitro group was selected as a strong electrophilic group to promote the nucleophilic substitution reaction. After the nucleophilic addition reaction between probe and hydrogen sulfide with delicate structure, strong nucleophile, 2, 4-dinitrophenol departure quickly and the NIR fluorophore was released, which showed fluorescence emission at 741 nm, and the probe detection limit for hydrogen sulfide was calculated as 96 nM. Interestingly, because of the positive charge in the hemiocyanine, the probe can locate efficiently in the mitochondria. This fluorescent probe with excellent performance was used to detect the endogenous levels of hydrogen sulfide in vivo. This work provides guidance for the design of multifunctional and high-performance fluorescent probes.
View MoreAngelisun(Chongqing) Pharmaceutical Co., LTD.
Contact:+86-23-68030926-816
Address:D1-7 Tech & Entrepreneurs Park, Kecheng Road, Erlang Hi-Tech Areas, Chongqing, China
Contact:0086-29-88315623
Address:S711, Innovation Bldg No.25 Gaoxin 1st Rd, Xian P.R of China 710075
Tianjin Jiuri New Materials Co., Ltd.
Contact:+86-22-58889220
Address:C-5/6, Vison Hill, No.1 Gonghua Road, Huayuan Hi-tech Park, Tianjin, China.
website:http://www.oceanchem-group.com
Contact:86-536-8596048
Address:9th floor,Building B future Plaza, No.88.Fenghuang Street,Weifang,Shandong,China
website:http://www.angchenchem.com
Contact:+86-510-88302099 82327577
Address:Rm. 404/405, Floor 4th, No. 983 FengXiang Road, Wuxi, China
Doi:10.1021/om000606w
(2000)Doi:10.1021/jo00231a040
(1987)Doi:10.1021/jm500522y
(2014)Doi:10.1016/S0040-4039(00)99086-5
(1989)Doi:10.1002/ardp.19883210115
(1988)Doi:10.1002/bkcs.10067
(2015)