1101103-75-6Relevant academic research and scientific papers
Resolution of N-Protected amino alcohols by porcine pancreatic lipase
Magrioti, Victoria,Fotakopoulou, Irene,Athinaios, Nicolaos,Anastasopoulou, Panoula,Constantinou-Kokotou, Violetta,Kokotos, George
experimental part, p. 159 - 162 (2010/08/19)
The resolution of 2-amino alcohols protected by urethane-type groups either via porcine pancreatic lipase (PPL) hydrolysis of the corresponding racemic acetates or via PPL catalyzed transesterification of racemic alcohols was studied. In both cases, Boc protecting group led to better chemical yields and enantiopurities than Z and Fmoc protecting groups. Furthermore, a simple and efficient method for the synthesis of the medicinally interesting optically pure (R)-2- aminohexadecanol was developed.
A facile method for the preparation of MOM-protected carbamates
Barnes, David M.,Barkalow, Jufang,Plata, Daniel J.
supporting information; experimental part, p. 273 - 275 (2009/08/08)
(Chemical Equation Presented) A novel method for the preparation of MOM-protected carbamates is described that avoids the use of MOM-Cl, a regulated carcinogen. The two-step, one-pot procedure generates a reactive N-chloromethyl carbamate that is quenched
