1101173-93-6

Basic information

• Product Name: 3-bromo-1,2,4-thiadiazol-5-amine
• Synonyms: 3-bromo-1,2,4-thiadiazol-5-amine;3-broMo-5-aMino-1,2,4-thiadiazole
• CAS NO: 1101173-93-6
• Molecular Formula: C₂H₂BrN₃S
• Molecular Weight: 180.02638
• Mol File: 1101173-93-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 223-225℃ (dec.)
• Boiling Point: 509.6°C at 760 mmHg
• Flash Point: 262°C
• Appearance: /
• Density: 1.84g/cm³
• Vapor Pressure: 3.3E-11mmHg at 25°C
• Refractive Index: 1.679
• PKA: -0.19±0.50(Predicted)
• CAS DataBase Reference: 3-bromo-1,2,4-thiadiazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-1,2,4-thiadiazol-5-amine(1101173-93-6)
• EPA Substance Registry System: 3-bromo-1,2,4-thiadiazol-5-amine(1101173-93-6)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:
• Safety Statements: S26:; S37/39:
• HazardClass: IRRITANT
• Hazardous Substances Data: 1101173-93-6(Hazardous Substances Data)

Usage

General Description

3-bromo-1,2,4-thiadiazol-5-amine is a chemical compound with the molecular formula C2H3BrN4S. It is a derivative of the heterocyclic compound thiadiazole, which contains a five-membered ring with sulfur and nitrogen atoms. The presence of a bromine atom at the 3-position and an amine group at the 5-position makes this compound potentially useful in various chemical reactions and pharmaceutical applications. It may have potential as a building block for the synthesis of other organic compounds or as a starting material for the development of new drugs. Additionally, its unique structure and reactivity may make it valuable for chemical research and development.

InChI:InChI=1/C4H3N3O4/c8-4(9)3-2(7(10)11)1-5-6-3/h1H,(H,5,6)(H,8,9)

Upstream product

• 37159-60-7 3-bromo-5-chloro-[1,2,4]thiadiazole 

Downstream Products

• 1101173-94-7 tert-butyl (3-bromo-1,2,4-thiadiazol-5-yl)carbamate 
• 17467-15-1 2-amino-4-phenyl-1,3,5-thiadiazole 

Relevant articles and documents

Pharmacological evaluation of novel (6-aminopyridin-3-yl)(4-(pyridin-2-yl)piperazin-1-yl) methanone derivatives as TRPV4 antagonists for the treatment of pain

A novel series of (6-aminopyridin-3-yl)(4-(pyridin-2-yl)piperazin-1-yl) methanone derivatives were identified as selective transient receptor potential vanilloid 4 (TRPV4) channel antagonist and showed analgesic effect in Freund's Complete Adjuvant (FCA) induced mechanical hyperalgesia model in guinea pig and rat. Modification of right part based on the compound 16d which was disclosed in our previous communication led to the identification of compound 26i as a flagship compound. In this paper, we described the details about design, synthesis and structure-activity relationship (SAR) analysis at right and left part of these derivatives (Fig. 1).

AROMATIC 5-MEMBERED HETEROCYCLIC DERIVATIVE HAVING TRPV4-INHIBITING ACTIVITY

The present invention is related to a compound represented by formula (I) wherein R1 is a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted aromatic carbocyclyl, or the like; X is —N(R3)—, —O—, or —S—; Y is ═C(R4)—, or ═N—; Z is —N(R7)—, —O—, or —S—; R2 is substituted or unsubstituted alkyloxy, or the like, or a group represented by the following formula: —(CR2aR2b)n—R2c, wherein R2a is each independently a hydrogen atom, halogen, or the like; R2b is each independently a hydrogen atom, halogen, or the like; R2a and R2b which are attached to the same carbon atom may be taken together to form oxo, a substituted or unsubstituted non-aromatic carbocycle, or the like; two of R2a which are attached to the adjacent carbon atoms and/or two of R2b which are attached to the adjacent carbon atoms may be taken together to form a bond; R2c is substituted or unsubstituted aromatic carbocyclyl, or the like; n is an integer from 1 to 3; R3 and R7 are each independently a hydrogen atom, substituted or unsubstituted alkyl, or the like; R4 and R5 are each independently a hydrogen atom, halogen, substituted or unsubstituted alkyl, or the like; R6 is a hydrogen atom, halogen, substituted or unsubstituted alkyl, or the like, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising thereof.

Facile synthesis of substituted 5-amino- And 3-amino-1,2,4-thiadiazoles from a common precursor

[Chemical Equation Presented] A novel approach to the synthesis of substituted 5-amino- and 3-amino-1,2,4-thiadiazoles beginning from a common precursor has been achieved. Derivatization by palladium-catalyzed Suzuki-Miyaura coupling enables the rapid pre