110130-71-7Relevant academic research and scientific papers
AROMATIC RING COMPOUND
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, (2015/01/18)
Provided is an aromatic ring compound having a GPR40 agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity, and is useful as an agent for the prophylaxis or treatment of diabetes and the like.
Design and synthesis of potent macrocyclic renin inhibitors
Sund, Christian,Belda, Oscar,Wiktelius, Daniel,Sahlberg, Christer,Vrang, Lotta,Sedig, Susanne,Hamelink, Elizabeth,Henderson, Ian,Agback, Tatiana,Jansson, Katarina,Borkakoti, Neera,Derbyshire, Dean,Eneroth, Anders,Samuelsson, Bertil
scheme or table, p. 358 - 362 (2011/02/27)
Two types of P1-P3-linked macrocyclic renin inhibitors containing the hydroxyethylene isostere (HE) scaffold just outside the macrocyclic ring have been synthesized. An aromatic or aliphatic substituent (P3sp) was introduced in the macrocyclic ring aiming
ASYMMETRIC DITHIOACETALS III: THE PREPARATION OF THE ENANTIOMERS OF 3-((((3-(2-(7-CHLOROQUINOLIN-2-YL)-(E)-ETHENYL)PHENYL)-3-DIMETHYLAMINO-3-OXOPROPYLTHIO)METHYL)THIO)PROPIONIC ACID (L-660,711) (MK-571), AN ANTAGONIST OF LEUKOTRIENE D4
Young, Robert N.,Gauthier, Jacques Yves,Therien, Michel,Zamboni, Robert
, p. 967 - 978 (2007/10/02)
The application of a novel method for the preparation of chiral dithioacetals to the synthesis of the enantiomers of L-660,711, an antagonist of leukotriene D4, is described.Reaction of 3-(t-butyldiphenylsilyloxymethyl)benzaldehyde or isophthal
