110143-52-7

Basic information

• Product Name: 3-(2-nitrovinyl)thiophene
• Synonyms: 3-(2-nitrovinyl)thiophene;(E)-3-(2-nitrovinyl)thiophene
• CAS NO: 110143-52-7
• Molecular Formula: C₆H₅NO₂S
• Molecular Weight: 155.17
• Mol File: 110143-52-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 269.7°Cat760mmHg
• Flash Point: 116.9°C
• Appearance: /
• Density: 1.335g/cm³
• Vapor Pressure: 0.0118mmHg at 25°C
• Refractive Index: 1.641
• CAS DataBase Reference: 3-(2-nitrovinyl)thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-nitrovinyl)thiophene(110143-52-7)
• EPA Substance Registry System: 3-(2-nitrovinyl)thiophene(110143-52-7)

Safety Data

• Hazardous Substances Data: 110143-52-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H5NO2S/c8-7(9)3-1-6-2-4-10-5-6/h1-5H/b3-1+

Upstream product

• 498-62-4 3-thiophene carboxaldehyde 
• 101756-40-5 2-(thiophen-3-ylmethylene)-malononitrile 
• 100-46-9 benzylamine 
• 75-52-5 nitromethane 

Downstream Products

• 1366043-10-8 (R)-1-benzyl-3-hydroxy-3-((S)-2-nitro-1-(thiophen-3-yl)ethyl)indolin-2-one 
• 59311-67-0 2-(3-thienyl)ethylamine 
• 1393357-02-2 (5R)-5-methyl-5-((R)-2-nitro-1-(thiophen-3-yl)ethyl)-2-(m-tolyl)oxazol-4(5H)-one 

Relevant articles and documents

Catalytic Asymmetric Construction of Tertiary Carbon Centers Featuring an α-Difluoromethyl Group with CF2H-CH2-NH2as the "building Block"

We report here for the first time a novel difluoromethylated ketimine building block condensed by thioisatin and difluoroethylamine, offering efficient access to a broad range of enantioenriched products bearing difluoroethylamine units (27 examples, ≤98% yield, >99% ee) in the presence of quinine-derived squaramide. Further transformation of the intermediate would generate a variety of versatile functional blocks like α-difluoromethyl amines, β-amino acid, and β-diamine with retention of the enantiomeric excess at the difluoromethyl-bound carbon.

Cinchona alkaloid and di-: Tert -butyldicarbonate-DMAP promoted efficient synthesis of (E)-nitroolefins

The synthesis of nitroolefins from aldehydes and olefins is generally limited by the formation of a mixture of cis and trans compounds. Here we report an alternative, metal-free protocol for the synthesis of β-nitroolefins from arylidinemalononitrile using cinchona alkaloid along with di-tert-butyldicarbonate-DMAP in high yields with total selectivity.

Synthesis and biological evaluation of N-acetyl-β-aryl-1,2-didehydroethylamines as new HIV-1 RT inhibitors in vitro

A variety of N-acetyl-β-aryl-1,2-didehydroethylamines were synthesized by direct reduction-acetylation of β-aryl-nitroolefins and assayed as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the first time. Compound 7a exhibited a TI value of >13.2 with CC50 value of >0.787 mM in C8166 cells. This structure-activity relationship (SAR) study provided a new lead for design and discovery of more potent and selective analogues act as NNRTIs.