110171-52-3

Upstream product

• 354-58-5 1,1,1-Trichloro-2,2,2-trifluoroethane 
• 107489-30-5 (2-methyl[1,1'-biphenyl]-3-yl)methyl cis,trans-2,2-dimethyl-3-formylcyclopropanecarboxylate 
• 7440-66-6 zinc 
• 107686-57-7 (2-methyl-3-phenylphenyl)methyl 2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylate 
• 754-17-6 1-chloro-1,1-dibromotrifluoroethane 

Downstream Products

• 107686-51-1 (2-methyl-3-phenylphenyl)methyl (1RS,3SR)-3-(1-acetoxy-2,2-dichloro-3,3,3-trifluoropropyl)-2,2-dimethylcyclopropanecarboxylate 
• 82657-04-3 (2-methyl-3-phenylphenyl)methyl (Z)-(1RS,3SR)-3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylate 
• 82657-04-3 (2-methyl-3-phenylphenyl)methyl (E)-(1RS,3SR)-3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylate 
• 82657-04-3 (1R,3S)-3-((Z)-2-Chloro-3,3,3-trifluoro-propenyl)-2,2-dimethyl-cyclopropanecarboxylic acid 2-methyl-biphenyl-3-ylmethyl ester 
• 110297-39-7 (2-methyl-3-phenylphenyl)methyl 2,2-dimethyl-3-(1-tosyloxy-2,2-dichloro-3,3,3-trifluoropropyl)cyclopropanecarboxylate 
• 110297-36-4 (2-methyl-3-phenylphenyl)methyl 2,2-dimethyl-3-(1-benzoyloxy-2,2-dichloro-3,3,3-trifluoropropyl)cyclopropanecarboxylate 

Relevant academic research and scientific papers

2,2-Dimethylcyclopropane-carboxylic acid derivatives

A 2,2-dimethylcyclopropanecarboxylic acid derivative having the formula: STR1 wherein R1 is an alkyl group or an aryl group, R2 is a hydrogen atom, an acyl group, a sulfonyl group or an alkyl group, and each of X1 and X2 is a halogen atom.

PRACTICAL AND STEREOCONTROLLED SYNTHESES OF BOTH (1R*,3S*)- AND (1R*,3R*)-3-(2-CHLORO-3,3,3-TRIFLUORO-1-PROPENYL)-2,2-DIMETHYLCYCLOPROPANECARBOXYLATES

The title compounds of (1R*,3S*) configuration were prepared from 3-formyl-2,2-dimethylcyclopropanecarboxylate by addition of CF3CCl2ZnCl, acetylation, and reductive β-elimination with zinc, whereas the (1R*,3R*) isomer was derived from Me2C=CHCH(OH)CCl2CF3 by diazoacetylation, Cu(II) catalyzed intramolecular cyclization, and the zinc reduction.

EFFICIENT CARBON-CARBON BOND FORMATION WITH THERMALLY STABLE 1,1-DIHALO-2,2,2-TRIFLUOROETHYLZINC REAGENT

The zinc carbenoids CF3CX2ZnX, prepared from CF3CX3 and zinc powder in dimethylformamide, were found thermally stable to add to aldehyde carbonyls in excellent yields.